DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and cdh23

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:XP_031762583.1 Gene:cdh23 / 100493009 XenbaseID:XB-GENE-957613 Length:3353 Species:Xenopus tropicalis


Alignment Length:2873 Identity:702/2873 - (24%)
Similarity:1116/2873 - (38%) Gaps:616/2873 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 KSSLSH----HSEMSLVLPHDTYPGFSIKKFK----------THPVKINGSSHS----GAAAYHM 109
            :|.|.|    ..:::|:..:|..|.||...:.          |..:||..:.:.    |..:|..
 Frog   434 ESVLDHVGYSQVKINLINENDNRPIFSQALYNISLYENVTVGTTILKIQATDNDIGSFGKVSYFF 498

  Fly   110 LDTDYSKYFTVLEDGV--VMTTADISPLVNRPVQLVVVEQTPNATNTHNLQLFVMHRNDMLRF-- 170
            .| |..::....:.||  |:|..|.. ...|....|:.........|..:::.|:..||.:..  
 Frog   499 SD-DPDRFSLDKDTGVITVITRLDYE-TTQRYTLTVIARDGGGEETTGRVRINVLDVNDNMPIFQ 561

  Fly   171 SGSLLDASGEVRENQPAGTRVRGVPLMQAFSGSILDEELATPKKVRYTIIDG---------NVDD 226
            ..|.|   |.:|||:|:   |..|..::|     .||:.|...::.|:|::.         ::.:
 Frog   562 KESYL---GAIRENEPS---VVTVVKLRA-----TDEDSAPNNQITYSILNASAFQSYFEISISE 615

  Fly   227 AFAL--------QERKAN----------------------------------------------- 236
            .:.:        .|:.:|                                               
 Frog   616 GYGVITVTRPLDYEQISNGVISLTVMAKDSGVPSLNSTVPVSIEVFDENDNPPTFSRSSYVITVM 680

  Fly   237 KNIQISAKSLVINGDD---------ESGVWLVTNRP----------------LDREERAHYDLSV 276
            :||...|..|.:|..|         ||.::.:...|                ||||.::.|.|.:
 Frog   681 ENIIAGATVLFLNATDLDRSREYGQESIIYSLDGSPQFRINARSGEITTTTLLDREAKSEYILII 745

  Fly   277 EASDVDG-----LDRTVSKIQITVLDENDNRPIFKSLDYKFAIAGQKSASMESNSSVTYQRFAIM 336
            .|  |||     ....::.:.||:||.|||.|.:|...|...:|    .....:|.||       
 Frog   746 RA--VDGGVGPNQKIGIATVNITLLDINDNAPQWKDEPYLINLA----EMTPPDSDVT------- 797

  Fly   337 GKVEATD---ADGDKIAYRLKSPSNVVIIVPQTGEIMLAG--------EPTSNELLIEVI--AHD 388
             .|.|.|   |:...:.|.:...:....:...||:|...|        .|...|::.:::  ..|
 Frog   798 -TVVAIDPDLAENGTLVYSISPLNKFYTLNSTTGKIRTTGVVLDRENPNPVEAEMMRKIVISVTD 861

  Fly   389 LRYPSLVSAKPAKVLLEFLAAEPVSFIMQHLEHDDINNHSHHREKRRVTRAVRPT-KRIEFTE-- 450
            ...|.|.:...|.|.:..|               |:|::.             || :.:.|..  
 Frog   862 RGRPPLRATSSATVSVNLL---------------DLNDND-------------PTFQNLPFIAEI 898

  Fly   451 ADGDTEGKSVFQL------EKETDKETFKIRDDNP---WVTVETNGAVRVKKKWDYEELGPEKTI 506
            .:|...|.||||:      |....:.|:::....|   :|...|.|.:......|.|::..    
 Frog   899 LEGTATGASVFQVVAIDLDEGLNGQVTYRMPVGIPQMDFVINSTTGLITSTAVLDREKIAA---- 959

  Fly   507 DFWVIITNMGHNAGI-KYTDNQRVIILVKDVNDEPPYFINRPLPMQAVVQLNAPPNTPVFTLQAR 570
             :::.:  :..:||. ..|....:.:.|.|||||.|.|.  |......:..|.|.:..|..|...
 Frog   960 -YYLRV--VASDAGTPSKTSTSTLTVSVLDVNDERPTFF--PTIYNVSLAENIPRDYIVARLNCT 1019

  Fly   571 DPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGTDLFQLDME----YVLYVKAEDQNGKVDD 629
            |.||..|  :.|||......|:|.|..|.|::||    :..||.|    |.|.::|.| ||...:
 Frog  1020 DADTGLNAELSYFITGGNQDGKFTVGFRDGILRT----VVNLDRETVASYTLVLEAID-NGPAGN 1079

  Fly   630 RRFQSTPEERLSIVG-GKRAPQFYMPSYEAEIPENQKKDSDIISIKAKSF--ADREIRYTLKAQG 691
            |: ..|....::::. ....|.|...||||.:|||....|.|:.::|...  .|..:.:.....|
 Frog  1080 RK-TGTATVSVTVLDINDNKPIFLKSSYEASVPENVPFSSSIVQLEATDADEGDNGLVWYRILSG 1143

  Fly   692 QGAGTFNIGPTSG-IVKLAKELDFEDLRQPHVYSLIVTA-TEDSGGFSTSVDLTIRVTDVNDNAP 754
            .....|.|...:| |::..:.|| .:....||  |:|.| ..|.|...:||.:.|.|.||||..|
 Frog  1144 NEKTNFRIDVNTGLIMRGVQPLD-RETNSSHV--LVVEAYNSDQGPMRSSVRVIIYVEDVNDEVP 1205

  Fly   755 KFELPDYQAHNVDEDIPLGTSILRVKAMDSDSGSNAEIEYLV---SDDHFAVD-SNGIIVNNKQL 815
            .|....|....:.|.:.:|||:..|:|.|.|:|....:.|.:   :|..|.:| |.|::.....|
 Frog  1206 VFTQQQYSRLGLRETVGIGTSVTVVRATDRDTGDGGLVTYKIISGADGKFDIDASTGLLTTIDYL 1270

  Fly   816 DADNNNAYYEFIVTAKDKGEPPKSGVATVRVYTKNKNDEEPKFSQQVYTPNVDENAGPNTLVTTV 880
            |.:....|| ..|:|.|:..|...|..|:.|...|:.||..:|:...|...:.||....|.|..|
 Frog  1271 DYETKTTYY-MNVSATDQAVPFNRGFCTIYVTLMNEPDEVVQFTSPTYKAVIIENIATGTEVVRV 1334

  Fly   881 VASDKDGDNVRFGFVGGGTSSGQ----FVIEDITGVIRLHNKAISLDKDK---YELNVTAMDDGS 938
            .|...|..| :..:....|:..|    |.|:.|||.|.:  |.: :|::|   |.|.|.|.|.|.
 Frog  1335 QARSIDNLN-QLSYKFDQTTYAQALALFKIDGITGAITV--KGL-VDREKGDFYTLIVVADDGGP 1395

  Fly   939 CCVNGDQTIHTSTAVVVVFITDVNDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQ 1003
                     ...:|||.:.:.|.|||.|.|...|.....|.|..|.|..|..|.|.|.|.|.||.
 Frog  1396 ---------KKDSAVVSITVLDENDNSPQFDPTSDSVVNVPEDCPTGRRVALVQARDPDDGNNGL 1451

  Fly  1004 VKYSIVQ-QPNQKGTKFTVDEETGEVSTNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVE 1067
            |.:|:.. .|:......|.:...|||...|..|||..:  ..::.::|:|.|.|......:.||.
 Frog  1452 VTFSLTAGNPSGIFEIRTTNNTLGEVFLIKSIDREVQE--LYTLKIQASDSGSPPRRSEYTLTVN 1514

  Fly  1068 ITDVNDNPPLFDRQ-KYVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEI 1131
            :.|||||||:||:. .|..:|.::...||:::||:|:|:|...|..:.|.:|   ..|:...|.:
 Frog  1515 VNDVNDNPPVFDKPFGYNVSVYENVGGGTSVIRVNATDKDKGLNSVLSYYIT---QGNEDLTFRM 1576

  Fly  1132 QAESGWIVLKKPLDGCYPRDR-----YRLRVSASDKGTPASAADVDVELDVVDRNNKPPIWDKSI 1191
            ...:|.|..:..     |.||     |:|.|:..|:|.||.:|...|.:.::|.|:..|::...:
 Frog  1577 DRLTGEIATRPA-----PPDREKQSFYKLVVTVEDEGNPALSATTTVYVTILDENDNSPVFKSPV 1636

  Fly  1192 Y------GPIHIRENVTVGTVVTSVKASSGIEG-NPTVFYRLMPGSTAQTNKFHTFYLQQRPDNG 1249
            |      ||:      ::.:|:.:..|....|| |.||.|.:..|:..:|...          |.
 Frog  1637 YEVTRDEGPL------SLNSVILTTTAVDQDEGPNGTVTYSISAGNVQETFSI----------NN 1685

  Fly  1250 DTWADIKVNHPLDYE-SIKEYNLTIRVENN---GAQQLASEATVYIMLEDVNDEIPLFTEREQE- 1309
            .|.. |:|...|||| .:..|.|.:...:.   ..::|.|.|||.:.:.|:||..|.|.:..:. 
 Frog  1686 ATGL-IRVVKELDYEVCLGRYTLIVTATDRCPIVQRRLTSTATVLVNVNDINDNWPTFPKPYEGP 1749

  Fly  1310 -TVLEGEPIGTKVTQVNAIDKDGTFPNNQVYYYIVDSPRNEGKEF---FEINLQSGEIFTKTVF- 1369
             .:.||:| |.:|....|.|||... |.||.|.||      |.:.   |.|:...|::..:..: 
 Frog  1750 FEITEGQP-GPRVATFKADDKDSGL-NGQVEYSIV------GGDLLGDFVISSVEGDLRVRKDYE 1806

  Fly  1370 -DREKKGAYALEVEARDGAPSARPNSNGPNSVTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDI 1433
             |||....|.:.:.|:|       ..|.|.|.|..:.|.:.|.|||.|..........:.||..:
 Frog  1807 LDRENIAFYNITIMAKD-------RGNPPFSSTAVVEIRVLDINDNDPILLNLPQNISISENTPV 1864

  Fly  1434 QHTVLTVTAKDHD--ESSRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELRLAASD- 1495
            ...:..:.|.|.|  .::.:.:.||:||:..||::...||.:||...||.|....|:|.:...| 
 Frog  1865 STPITRILASDADTGRNALLTFNITAGNLENAFSINENTGIVYVNRQLDREKISEYKLTITVKDN 1929

  Fly  1496 -----NLKENYTTVIIHVKDVNDNPPVFERPTYRTQITEEDDRNLPKRVLQ--VTATDGDKDRPQ 1553
                 |.:.::..:|:.:.|.|||.|:|.:.:|..::||......|..||.  |.|.|.|.....
 Frog  1930 PENARNSRRDFDVLIVTISDENDNRPLFTQGSYLAELTENSPEGTPITVLNGPVLALDNDIGSNA 1994

  Fly  1554 NIVYFLTGQGIDPDNPANSKFDINRTTGEIFVL--KPLDRDQPNGRPQWRFTVFAQDEGGEGLVG 1616
            .:.|.|.|..|       :.|.||.:||.:.|.  |.:||:. ...|....|:.|:|.|  .|..
 Frog  1995 VVSYRLLGAQI-------NLFTINNSTGVVTVRAGKVIDRES-FLNPILDLTLVAEDIG--KLNS 2049

  Fly  1617 YADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVI 1681
            .|.:.:.:.|.|||.|||.......::.||...|..|:.:||.|.|   .|.|.:|.|.||....
 Frog  2050 TARLVLTVLDANDNRPIFSPSSVTVHLRENSPPGFSVVKVTATDAD---SGINQQLSYRIESGAQ 2111

  Fly  1682 EEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDGGG--LKGTGTASIRVKDINDMPP 1744
            :.      |.|:..||||:.|...:|||....|.:.|||.|.|.  |.|:.|.||.:.|:||.||
 Frog  2112 DR------FLIDAFTGVIRVANVTVDREEKDTYKLIVVATDQGAVPLSGSITVSILIDDVNDCPP 2170

  Fly  1745 QFTKDEWFTEVDETD--GTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADKFTMVRNNDG-- 1805
            :|........|.|:.  ||.:.|     ||..|.|...:.:|.:|:..... |..:::.|..|  
 Frog  2171 EFVNPIQTVSVLESAEVGTVVAE-----VTAIDRDLNPRLEYYIIEILATD-DTNSLIPNQQGVF 2229

  Fly  1806 -----TGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHF 1865
                 |||:.:...|:.|  |.:. :...|.|.|...:..:.......:.:.|.:.|:|||.|.|
 Frog  2230 EINFKTGSVMVKSNLNRE--LVAT-YDITISVYDNASEVVDRSVSAPNAKLTVNILDVNDNTPRF 2291

  Fly  1866 ERANVEV---SVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDR-QRQFAINQNGSVTIQR 1926
            ....|..   .:.|....||.|....|.|||:|...:::||:...... ..|...|..|.:...|
 Frog  2292 RPFGVTAFTERIVEGATPGTTLISVSAVDPDKGPNGQITYSLHNLVPAGYLQLEDNMAGKIIANR 2356

  Fly  1927 SLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKD--YRPVLPEHVPPRKVVE 1989
            ::|.|.|......:.|.|:|||.::|...:.:.:.|||||.|.|.:.  .:||..:......|::
 Frog  2357 TVDYEQVQWLNFTVRASDNGSPRRSAEVPVYLQIVDINDNNPIFSQSSYQKPVFEDIQLGATVLQ 2421

  Fly  1990 ILATDDD-------DRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDR 2047
            |.|||.|       ..|..:|.. :|.::|:..||.                   ::|:|   ||
 Frog  2422 IKATDADSGRFALIQYSLVDGEG-KFGINPTTGDIY-------------------ILSTL---DR 2463

  Fly  2048 EQQKEYMIPIVIKDH----GSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIGR 2108
            |::..|.:..:.:|:    .|.....:..:.:.:.||||.:.|..........|:.:...|.:..
 Frog  2464 EKKDHYTLTAIARDNPGDIASNRRENSVQVLITVLDVNDCRPQFSKSQFSTSVYENEPEGTSVIT 2528

  Fly  2109 VYVYDLDDWDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTRE-GRYHLRFKVYDR--------- 2163
            :...|||:.|.....:..|......|.:|:|||::|.|...:. .|::|.....|:         
 Frog  2529 MSATDLDEGDNGVVTYNLEGPGSEAFLIDKDSGLITSRRLLQSFERFNLTVVATDKGRPPLWGTT 2593

  Fly  2164 --KHTQTDIPANVTVTVR-----------EIPHEAVVN-----------SGSVRLSGISDEDFIR 2204
              |....|:..|..|.||           |||.::.|.           :|:||.:.:......:
 Frog  2594 MLKVDVIDVNDNRPVFVRPPNGTILHIKEEIPLKSTVYEVYATDNDEGLNGAVRYNLLKTGAGTK 2658

  Fly  2205 VWNYRTQSMSRSKMDRFRDKLADLLNTERE-----NVDIFSVQLKRKHP---------PLTDVRF 2255
            .|.|.|       :|.....:...|..:||     |:.|.:..|.:..|         .|.|:  
 Frog  2659 DWEYFT-------IDSTSGLIQTALRLDREKQAMYNLIIVAYDLGQPVPYETMLPLQVALDDI-- 2714

  Fly  2256 SAHGSPYYKPVR--LNGIVLMHREEIEKDVGI-NIT-MVGIDE----CLY-----ENQ------M 2301
            ..:...:.:|.|  |....|..||..:....: |:: .|.:||    .:|     .||      :
 Frog  2715 DDNEPAFIRPPRGALQYQTLSVREHSKPGTVVGNVSGAVDVDEGSNAIVYYFIATGNQDNNFLLI 2779

  Fly  2302 CEGSCT--NSLEISPLPY---MVNANKTA------LVGVRVDTIADCTC------------GARN 2343
            .||..|  .:|:....||   :|.|:...      .:|.:.|...|.|.            ....
 Frog  2780 PEGKLTVLKNLDREKEPYYSIIVKASSNRSWTPGNSLGKKFDPATDSTLQEVRVYLEDINDQPPR 2844

  Fly  2344 FTKPESCRTTPCHNGGRCVDTRFGPH------CSCPVGYTGPRCQQTTRSFRGNGWAWYPPLEMC 2402
            |||||       :..|...|.:.|..      ....||              .|...:|      
 Frog  2845 FTKPE-------YTAGVATDAKVGSELIKVLAVDADVG--------------NNSLVFY------ 2882

  Fly  2403 DESHLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPR---LLIDFGSGTLELRV 2464
              |.|.:.:|...              ..|...:.:..|:|...|..|   |...:..|...:.:
 Frog  2883 --SILGIRYIKLN--------------SNDSVEVKNIFAIENTTGIVRTFDLFTAYSPGYFIVDI 2931

  Fly  2465 KTKKTLDDGEWHRIDLF--WDTESIRMVVDFCKSAEIAEMEDGTPPEF--------------DDM 2513
            |........:...:.::  .|.:.:::|::     ||.:...|...||              ||:
 Frog  2932 KAVDLAGHNDTAVVGIYILRDDQRLKIVIN-----EIPDRVRGFEEEFIRLLSNITGAIVNTDDV 2991

  Fly  2514 S--CQARGQI-------------PPFNEYLNVNAPLQVGGLYREQFDQSLYFWHYMPTAKGFDGC 2563
            .  ...:|::             ...|..|:|...:|:....:||                    
 Frog  2992 QFHVDKKGRVNFAQTDMLIHVVNRDTNRILDVERVIQMIDENKEQ-------------------- 3036

  Fly  2564 IRNLVHNSKLYDL 2576
            :|||..|..:.|:
 Frog  3037 LRNLFRNYNVMDV 3049

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637 39/216 (18%)
Cadherin_repeat 337..396 CDD:206637 14/71 (20%)
E_set 449..541 CDD:298831 23/103 (22%)
Cadherin_repeat 549..>625 CDD:206637 25/81 (31%)
Cadherin_repeat 655..752 CDD:206637 32/100 (32%)
Cadherin_repeat 765..853 CDD:206637 27/91 (30%)
Cadherin_repeat 862..964 CDD:206637 31/108 (29%)
Cadherin_repeat 973..1074 CDD:206637 32/101 (32%)
Cadherin_repeat 1083..1166 CDD:206637 24/87 (28%)
Cadherin_repeat <1219..1298 CDD:206637 22/82 (27%)
Cadherin_repeat 1310..1414 CDD:206637 32/108 (30%)
Cadherin_repeat 1423..1514 CDD:206637 25/98 (26%)
Cadherin_repeat 1522..1630 CDD:206637 32/111 (29%)
Cadherin_repeat 1638..1741 CDD:206637 36/104 (35%)
Cadherin_repeat 1762..1861 CDD:206637 22/105 (21%)
Cadherin_repeat 1871..1966 CDD:206637 27/98 (28%)
Cadherin_repeat 1974..2083 CDD:206637 25/119 (21%)
EGF 2350..2380 CDD:278437 5/35 (14%)
LamG 2385..2570 CDD:238058 32/218 (15%)
EGF_2 <2605..2631 CDD:285248
Laminin_G_2 2665..2800 CDD:280389
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
cdh23XP_031762583.1 Cadherin_repeat 43..129 CDD:206637
Cadherin_repeat 137..232 CDD:206637
Cadherin_repeat 241..345 CDD:206637
Cadherin_repeat 353..455 CDD:206637 4/20 (20%)
Cadherin_repeat 464..556 CDD:206637 17/93 (18%)
Cadherin_repeat 564..666 CDD:206637 17/112 (15%)
Cadherin_repeat 674..773 CDD:206637 24/100 (24%)
Cadherin_repeat 781..885 CDD:206637 24/130 (18%)
Cadherin_repeat 893..989 CDD:206637 21/102 (21%)
Cadherin_repeat 998..1097 CDD:206637 29/104 (28%)
Cadherin_repeat 1105..1202 CDD:206637 31/99 (31%)
Cadherin_repeat 1217..1307 CDD:206637 27/90 (30%)
Cadherin_repeat 1316..1412 CDD:206637 31/108 (29%)
Cadherin_repeat 1423..1521 CDD:206637 32/99 (32%)
Cadherin_repeat 1531..1628 CDD:206637 30/104 (29%)
Cadherin_repeat 1636..1738 CDD:206637 30/118 (25%)
Cadherin_repeat 1750..1845 CDD:206637 32/109 (29%)
Cadherin_repeat 1853..1953 CDD:206637 25/99 (25%)
Cadherin_repeat 1961..2063 CDD:206637 32/111 (29%)
Cadherin_repeat 2071..2167 CDD:206637 36/104 (35%)
Cadherin_repeat 2178..2287 CDD:206637 26/117 (22%)
Cadherin_repeat 2299..2396 CDD:206637 27/96 (28%)
Cadherin_repeat 2404..2502 CDD:206637 24/120 (20%)
Cadherin_repeat 2511..2605 CDD:206637 19/93 (20%)
Cadherin_repeat 2618..2717 CDD:206637 20/107 (19%)
Cadherin_repeat 2733..2840 CDD:206637 22/106 (21%)
Cadherin_repeat 2849..2950 CDD:206637 19/143 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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