DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and cdh24

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_031747121.1	Gene:	cdh24 / 100489868	XenbaseID:	XB-GENE-995690	Length:	795	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	212/743 - (28%)
Similarity:	335/743 - (45%)	Gaps:	140/743 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1511 VNDNPPVF----ERPTYRTQ---------ITEEDDRNLPKRVLQVTATDGDKDRPQ-NIVYFLTG 1561
            ||..||.|    ..|..||:         :.||...  |:.|| :.....|.||.: ...|.|||
Frog    33 VNGVPPAFYSWGHSPPLRTKRSWVWNQFFVIEEYAG--PEPVL-IGRLHTDADRGEGRAKYLLTG 94

  Fly  1562 QGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQDEGG---EGLVGYADVQVN 1623
            :|      |.|.|.|:..||.|.|.|.|||::     :..:.:.||....   ..|...:...:.
Frog    95 EG------AGSVFVIDEKTGNIHVTKSLDREE-----KAEYVLLAQAVDKLTLRPLEPPSQFIIK 148

  Fly  1624 LKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSP 1688
            ::|||||.|:|....|...|.|....|..|:.:||.|.|||..|::|||||:|.:       |.|
Frog   149 VQDINDNPPVFLHPPYRATVPEMSNVGTSVIQVTASDADDPTYGNSARLVYTILE-------GQP 206

  Fly  1689 IFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDINDMPPQFTKD 1749
            .|.::|.||||:||:..:|||...::.:.:.|.|    .|||.|:.|.::.:.|:||.||:|.::
Frog   207 YFSVDPQTGVIRTAIPNMDRETQNEFLVVIQAKDMGGHVGGLSGSTTVTVTLSDVNDNPPKFPQN 271

  Fly  1750 EW-FTEVDETDGTALPEMPILTVTVHDED--ETNKFQYKVIDNSGYGADKFTMVRNNDG-TGSLK 1810
            .: ||.::    ...|...|..:..||.|  |.....|.::|  |...|.|::|.::.| .|.|:
Frog   272 LYQFTVLE----NIAPGSVIGRLRAHDPDIGENAAMSYSILD--GDAGDTFSVVSDSAGQDGILR 330

  Fly  1811 IVQPLDYEDQLQSNGFRFRIQVND---------KGEDNDNDKYHVAYSWVVVKLRDINDNKPHFE 1866
            :.:.||:|.|   ..|.||::|.:         :|...|       .:.|.|.:.|:|: .|.|.
Frog   331 VRKSLDFESQ---RSFTFRVEVMNTVIDPQYIRRGPFKD-------VTTVRVTVVDVNE-PPLFS 384

  Fly  1867 RANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAIN-QNGSVTIQRSLDR 1930
            :....:||.|:...|..:...:|.|||. ..|.:|||||..||.:..|:|: ::|::....||||
Frog   385 QELYTMSVLENLPPGAIVGVVQAQDPDL-HSSSISYSIDPLSDPEVLFSIHPEDGTILTSVSLDR 448

  Fly  1931 EVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDD 1995
            ||...|.:.:.|.:..|....:.|.:.:.|.|:|||.|:..:.|:|.:.:|..|.:|::.:...|
Frog   449 EVRGEHSITVRASESDSSSHVSQAGVLIKVLDVNDNPPRLAEVYKPHVCDHAQPGQVIQTVRVRD 513

  Fly  1996 DDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMA-VISSLRSFDREQQKEYMIPIVI 2059
            .|  ..|| .|.|: .|:|  |...:|.:..     |.||.| ::....||.|.|:..:::||.|
Frog   514 AD--SENG-IFSFQ-SPAA--ISDGNFTLRD-----NKDGSASLLVRHSSFWRSQKDIFLVPIEI 567

  Fly  2060 KDHGSPAMTGTSTLTVII------GDVNDNKMQPGSKD--------------------IFVYNYQ 2098
            .|:|.|.:|.|.||||.:      |.|....:..||..                    :.:::.|
Frog   568 MDNGDPPLTSTDTLTVSLCHCETGGAVLTCHLTTGSAAGLSTPALLAILACALSLLALVSLFSLQ 632

  Fly  2099 GQSPDTPIG---------RVYVYDLDDWDLPD-KKFYWEAMEHPRFKLDEDSGMVTMRAGTREGR 2153
            .:...:|:.         .:..||.:.....| :.|...|::.|             :.|...|.
Frog   633 RRHKPSPLSLCEDEDVRENIITYDDEGGGEQDTQAFDMSALQPP-------------QTGLTGGF 684

  Fly  2154 YH-----LRFKVYDRKHTQTDIPANVTV 2176
            :|     :..:|..|..|.:..||:|.|
Frog   685 FHPPRMDVLPRVPPRPTTHSPQPASVDV 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637	2/2 (100%)
		Cadherin_repeat	1522..1630	CDD:206637	33/120 (28%)
		Cadherin_repeat	1638..1741	CDD:206637	39/106 (37%)
		Cadherin_repeat	1762..1861	CDD:206637	29/110 (26%)
		Cadherin_repeat	1871..1966	CDD:206637	32/95 (34%)
		Cadherin_repeat	1974..2083	CDD:206637	37/115 (32%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
cdh24	XP_031747121.1	CA	79..157	CDD:214520	28/88 (32%)
		Cadherin_repeat	163..264	CDD:206637	40/107 (37%)
		Cadherin_repeat	273..357	CDD:206637	25/92 (27%)
		Cadherin_repeat	388..484	CDD:206637	32/96 (33%)
		Cadherin	510..586	CDD:421759	30/86 (35%)
		Cadherin_C	633..787	CDD:395833	17/93 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11246
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000