DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN and celsr3

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:XP_031757039.1 Gene:celsr3 / 100489102 XenbaseID:XB-GENE-852799 Length:3718 Species:Xenopus tropicalis


Alignment Length:2109 Identity:529/2109 - (25%)
Similarity:823/2109 - (39%) Gaps:580/2109 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   974 YYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGTK-FTVDEETGEVSTNKVFDRE 1037
            |..:|.|..|.|:|||.:.|.|.|.|..|:::|::....|.|..: |::|..||.:||.::.|||
 Frog   669 YQVQVAENQPPGTPVITMSAQDPDTGEAGRLRYTMDALMNSKSLELFSIDSVTGLISTIEILDRE 733

  Fly  1038 GDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQDASIGTNILRVSA 1102
            ..|..:..|:  |.|.|.|.|.......:.::|.||:.|||::.:|.|:::::...|..||::.|
 Frog   734 SMDLHYFRVS--AIDHGTPRLSATTMVAITVSDRNDHSPLFEQSEYRESIRENVEEGYPILQLRA 796

  Fly  1103 SDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVLKKPLDGCYPRDRYRLRVSASDKGT--- 1164
            :|.|:..|..|.|........:.:  |||.|.||.|.....:|. ..|::|.|.|.|||:|.   
 Frog   797 TDMDSQANANIKYRFVNEQAAHSV--FEIDARSGLITTSGQVDR-EKREKYSLIVEASDQGKDPG 858

  Fly  1165 PASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGTVVTSVKASS-GIEGNPTVFYRLMP 1228
            |.|:. |.|::.::|.|:..|.:.:..| .:.:||::...|.:..|.|:. ..:.|..|.|.::.
 Frog   859 PRSST-VKVDITILDENDNVPQFSEKRY-IVQVREDIKTHTEIVRVTATDIDKDSNALVHYNIIS 921

  Fly  1229 GSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQQLASE-ATVYIM 1292
            |     |....|.:.      ....::::..|||:|:.:||.|.:|.::.|...|::. .|:.|.
 Frog   922 G-----NSRGQFSID------SVTGEVQIVTPLDFETEREYTLRVRAQDAGRPPLSNNTGTISIQ 975

  Fly  1293 LEDVNDEIPLFTERE-QETVLEGEPIGTKVTQVNAIDKD-GTFPNNQVYYYIV----DSPRNEGK 1351
            :.||||..|:|.... |.:|||..|:|..:..:.|||.| |  .|::|.|.:.    :||     
 Frog   976 VVDVNDHAPIFVSTPFQVSVLENAPLGHSIIHIQAIDADYG--ENSRVEYKLTGMKPESP----- 1033

  Fly  1352 EFFEINLQSGEIFTKTVFDREKKGAYALEVEARD-GAPSARPNSNGPNSVTKFIRIGIADKNDNP 1415
              |.||..:|.|......|||....|...||||| |.||.        |.:..:.|.|.|.|||.
 Frog  1034 --FVINSATGWITVSGPLDREMVEQYVFGVEARDHGNPSL--------SASAGVTITIMDVNDNR 1088

  Fly  1416 PYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGAFAVKNM--TGAIYVAGA 1478
            |.|.:..|...::|:..:..:||:|||.|.|.:|.|.|:||.||....:|:...  :|.|.::..
 Frog  1089 PEFTQREYFIRLNEDATVGTSVLSVTAIDRDVNSAITYQITGGNTRNRYAISTQGGSGLITLSLP 1153

  Fly  1479 LDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQITEEDDRNLPKRVLQVT 1543
            |||:..|||.|.:.|||.:..:...|.|::.|.|.:.|||:...|...|.|  ||.:...|:.::
 Frog  1154 LDYKQERRYVLTVTASDRILHDNCYVHINITDANTHRPVFQSAHYPVDINE--DRPIGSTVVIIS 1216

  Fly  1544 ATDGDKDRPQNIVYFLTGQ----GIDPDNPANSKFDINRTTGEIFVLKPLD-RDQPNGRPQWRFT 1603
            |:|.|......|.|.|...    .||||            ||.|.:...|| .||..    :...
 Frog  1217 ASDEDVGENARITYSLEDNIPQFRIDPD------------TGAITLRAMLDYEDQVT----YTLA 1265

  Fly  1604 VFAQDEG--GEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNE 1666
            |.|:|.|  .:....|.::.||  |:|||||.|....|.|.|:|:......|:.::|.|.|   .
 Frog  1266 VIAKDNGIPQKSDTTYVEIMVN--DVNDNAPQFANTQYHGIVSEDAPPFTSVVQISATDRD---S 1325

  Fly  1667 GSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGT 1731
            .||.|:.|:.:..    :.|...|.|||.:|:|:| |..||||..|.|.:...|:|.|       
 Frog  1326 HSNGRVQYTFQNG----DDGDGDFTIEPTSGIIRT-VRKLDRESVPFYELTAYAVDRG------- 1378

  Fly  1732 ASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADK 1796
                      |||                                                    
 Frog  1379 ----------MPP---------------------------------------------------- 1381

  Fly  1797 FTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDN 1861
                          :..|:             |||                     |.::|:|||
 Frog  1382 --------------LRSPV-------------RIQ---------------------VAVQDVNDN 1398

  Fly  1862 KPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDR---QRQFAINQNGSVT 1923
            .|.|.....||.|.|::.||:.:.|.||||||:|..:::.|.|...:..   |..|.   :|.:|
 Frog  1399 APVFPADEFEVYVKENSIVGSVVGKIKATDPDEGPNAQIMYQIVEGNIPEIFQMDFF---SGELT 1460

  Fly  1924 IQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVP----- 1983
            ....||.|..|.:   ::.:...|.|..:.||:.:.:.|.|||:| .||:::.:...::.     
 Frog  1461 ALIDLDYEAKPEY---VIVVQATSAPLVSRATVRIKLIDQNDNSP-VLKNFQILFNNYISNSSNT 1521

  Fly  1984 -PRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDR 2047
             |..|:..:            |.:    ||...|.:                       |.:|:|
 Frog  1522 FPSGVIGKI------------PAY----DPDVSDRL-----------------------LYTFER 1547

  Fly  2048 EQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVY 2112
            ..:    :.::|.:|.|             |::..::                            
 Frog  1548 GNE----LSLLIVNHSS-------------GELRLSR---------------------------- 1567

  Fly  2113 DLDDWDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTREGRYHLRFKVYDRKHTQTDIPANVTVT 2177
                                  |||.:..:|.....|          |.|..|:.|   |...:.
 Frog  1568 ----------------------KLDNNRPLVASMLVT----------VTDGIHSVT---AQCVLR 1597

  Fly  2178 VREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDKLADLLNTERENVDIFSVQ 2242
            |..|..:.:.||.:|||..:|.|.|:           ...:..|.:.::.:|.|.:|::.||::|
 Frog  1598 VLIITEDMLSNSITVRLENMSQERFL-----------SPLLTSFLEGVSTVLATPKEDIFIFNIQ 1651

  Fly  2243 LKRKHPPLTD-------VRFSA---HG--SPYYKPVRLNGIVLMHREEIEKDVGINITMVGIDEC 2295
            ..      ||       |.|||   ||  |.:.....|...:.|.|..:.....:.:.....:.|
 Frog  1652 ND------TDVAGSVLNVSFSALAPHGDRSQFLSSEDLQEQLYMKRMTLTSASMLEVLPFDDNVC 1710

  Fly  2296 LYENQMCEG--SCTNSLEI-SPLPYMVNANKTAL-------VGVRVDTIADCTCGARNFT----- 2345
            |.|  .||.  .|.:.|:. |..|::  |:::.|       .|:|      |.| .:.||     
 Frog  1711 LRE--PCENYMKCISVLKFDSSAPFI--ASESILFRPIHPITGLR------CRC-PQGFTGDYCE 1764

  Fly  2346 -KPESCRTTPCHNGGRCVDTRFGPHCSCPVGYTG------------------------------- 2378
             :...|.:.||.|||.|.....|..|.|...:||                               
 Frog  1765 IEINLCYSNPCQNGGVCARREGGYTCMCRERFTGDNCEVDSGSGRCVPGVCRNGGTCVNLAEGGF 1829

  Fly  2379 -----------PRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPPERD 2432
                       |.|:.:||||....:..:..|.......|||.|.|::.:||:.|||.:....  
 Frog  1830 TCQCPSGGFEKPFCELSTRSFPPKSFVMFRGLRQRFHMSLSLSFATKERNGLLFYNGRLNEKH-- 1892

  Fly  2433 ETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFW--------------- 2482
                 ||||:|:..|..:|....|..:..:.......:.||.||.:.|.:               
 Frog  1893 -----DFIAVEINDGQVQLKYSTGESSTLVTPYVAGGVSDGRWHTVLLRYYNKPKTGSMGVAQGP 1952

  Fly  2483 DTESIR-MVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGL--YREQF 2544
            ..|.|. :.||.|..:  ..::.|:  |..:.||.|.|......:.|::..||.:||:  ..|.|
 Frog  1953 SREKIAVLAVDDCDIS--VALKFGS--EIGNYSCAAEGVQSSSKKSLDLTGPLLLGGVPNLPENF 2013

  Fly  2545 DQSLYFWHYMPTA-KGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQTETTARCWEH 2608
                      |.| :.|.||:|:|..::|..|.|....:..:.|||......|....    |...
 Frog  2014 ----------PVAHREFIGCMRDLYVDNKKIDFASYIANNGTSAGCHGKHTFCDSNP----CKNG 2064

  Fly  2609 GNCVGSLSEARCHCRPGWTGPACNIPTIPTTFKAQSYVKYALSFEPDR-----FSTQVQ------ 2662
            |.|..:.....|:|..|:.|..|.|.           ::||..|....     |...|:      
 Frog  2065 GTCSVTWGSFNCNCPLGFGGKDCRIA-----------LQYAYQFNGSSLLSWDFKNDVKISVPWF 2118

  Fly  2663 --LRFRTREEYGELFRVSDQHNREYG--ILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQW 2723
              |.||||...|.|.:.   |..:|.  :.::..|.:.|..:..|.||..  |.|:.::||||:|
 Frog  2119 LGLAFRTRRADGVLLQA---HAGQYTTILCQLVSGLISFSVSRGSSRTSA--LLLDQMLVNDGKW 2178

  Fly  2724 HVVKV----------NRYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAEYTGV 2778
            |.:::          .||  ..::.||.|   .|.:|.. ||.: |...:.:.:|.||   .:|.
 Frog  2179 HDLQMELRDVRSGRETRY--VISINLDYG---FYQDTVT-VGSE-LHGLRVKNLYIGG---VSGP 2233

  Fly  2779 RTFEVYADYQKSCLDDIRL----EGKHLPLPPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPD 2839
            |  ||...:: .|:..:||    .|..||.|           :.|.|::.||.....|.:..||.
 Frog  2234 R--EVQNGFE-GCIQGVRLGETPSGITLPKP-----------SSALNVKPGCGVPNMCDSNPCPG 2284

  Fly  2840 PFECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMNGATCINLEPR--LRYRC------- 2895
            ...||:.|..|.|.|..|..    .:.|:|  .|...||.|...|.: :|.  :.|.|       
 Frog  2285 NSSCVNEWMSYSCVCHPGYY----GENCID--VCQLNPCENRGVCRH-QPSAPMGYTCECSKNHI 2342

  Fly  2896 ----------ICPDGFWGE------NCEL 2908
                      .||.|:||.      :|::
 Frog  2343 GRYCEHRLDQQCPKGWWGNATCGPCHCDV 2371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637 34/100 (34%)
Cadherin_repeat 1083..1166 CDD:206637 27/85 (32%)
Cadherin_repeat <1219..1298 CDD:206637 20/79 (25%)
Cadherin_repeat 1310..1414 CDD:206637 37/109 (34%)
Cadherin_repeat 1423..1514 CDD:206637 33/92 (36%)
Cadherin_repeat 1522..1630 CDD:206637 32/114 (28%)
Cadherin_repeat 1638..1741 CDD:206637 30/102 (29%)
Cadherin_repeat 1762..1861 CDD:206637 7/98 (7%)
Cadherin_repeat 1871..1966 CDD:206637 30/97 (31%)
Cadherin_repeat 1974..2083 CDD:206637 13/114 (11%)
EGF 2350..2380 CDD:278437 12/71 (17%)
LamG 2385..2570 CDD:238058 53/203 (26%)
EGF_2 <2605..2631 CDD:285248 7/25 (28%)
Laminin_G_2 2665..2800 CDD:280389 41/150 (27%)
EGF_CA 2869..2907 CDD:238011 14/62 (23%)
Cadherin_C 2952..3088 CDD:279398
celsr3XP_031757039.1 Cadherin_repeat 669..768 CDD:206637 34/100 (34%)
Cadherin_repeat 776..876 CDD:206637 33/103 (32%)
Cadherin_repeat 885..982 CDD:206637 27/108 (25%)
Cadherin_repeat 990..1087 CDD:206637 38/113 (34%)
Cadherin_repeat 1095..1189 CDD:206637 33/93 (35%)
Cadherin_repeat 1197..1292 CDD:206637 32/114 (28%)
Cadherin_repeat 1300..1398 CDD:206637 40/222 (18%)
Cadherin_repeat 1406..1500 CDD:206637 30/99 (30%)
Cadherin_repeat 1520..1601 CDD:206637 24/199 (12%)
EGF_CA 1767..1802 CDD:238011 12/34 (35%)
EGF_CA 1812..1844 CDD:238011 1/31 (3%)
LamG 1847..2030 CDD:238058 53/203 (26%)
EGF_CA 2056..2087 CDD:238011 8/34 (24%)
Laminin_G_2 2123..2252 CDD:396680 41/146 (28%)
EGF_CA 2277..2309 CDD:238011 10/35 (29%)
EGF_CA 2309..2347 CDD:238011 9/40 (23%)
EGF_Lam 2404..2449 CDD:214543
HormR 2453..2519 CDD:214468
GAIN 2536..2777 CDD:406802
GPS 2805..2854 CDD:413374
7tmB2_CELSR3 2865..3118 CDD:320659
TM helix 1 2868..2892 CDD:320659
TM helix 2 2901..2922 CDD:320659
TM helix 3 2932..2954 CDD:320659
TM helix 4 2973..2989 CDD:320659
TM helix 5 3008..3031 CDD:320659
TM helix 6 3054..3076 CDD:320659
TM helix 7 3080..3105 CDD:320659
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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