DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and cdh8

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_002935098.2	Gene:	cdh8 / 100486228	XenbaseID:	XB-GENE-1002704	Length:	810	Species:	Xenopus tropicalis

Alignment Length:	587	Identity:	181/587 - (30%)
Similarity:	287/587 - (48%)	Gaps:	79/587 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1545 TDGDKDRPQN--IVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQ 1607
            ||.|   |.|  |.|.|:|:|      |.:.|.||..||:|..:|.|||::   :.::..|..|.
Frog    98 TDLD---PGNTKIKYILSGEG------AGTIFVINDKTGDIHAMKRLDREE---KAEYTLTAQAV 150

  Fly  1608 D-EGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNAR 1671
            | :..:.|...::..:.::|||||||.|..|.|...|.|....|..|..:||.|.|||..|::|:
Frog   151 DRDTNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSIVGTYVTKLTATDADDPVYGNSAK 215

  Fly  1672 LVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTA 1732
            |||||.:       |.|.|.|||.|.:||||:..:|||...:|.:.:.|.|    .|||.||.|.
Frog   216 LVYSILE-------GQPYFSIEPHTAIIKTALSNMDREAREEYLVVIQAKDMGGHMGGLSGTTTV 273

  Fly  1733 SIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDED--ETNKFQYKVIDNSGYGAD 1795
            ::.:.|:||.||:|...::...|.|..|..   ..:..|..:|.|  :..|..:.:||  |.|.|
Frog   274 TVTLTDVNDNPPKFAMSQYQFVVPEDVGIG---DTVGRVKANDRDTGDNAKSSFDIID--GDGKD 333

  Fly  1796 KFTMV---RNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGED---------NDNDKYHVAY 1848
            .|.|.   :..||.  :::.:|||:|.:   ..:..:::..:...|         .|.
Frog   334 VFEMTTDPQTQDGL--IRLRKPLDFESK---KSYILKVEAANVNIDPRFISGVPFKDT------- 386

  Fly  1849 SWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQ 1913
            :.|.:.:.|. |..|.|......:.|.|:..:...:.:..|.|||... |.:.:||||.:|...|
Frog   387 ATVKITVEDA-DEPPVFSSPTYLLEVHENAVINGVIGQVSARDPDSSA-SPIRFSIDRHTDLDHQ 449

  Fly  1914 FAIN-QNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPV 1977
            |.|| .:|.:|:...||||....|.:.::|.:..:..:.:...:.:.|.|:|||||:|..||...
Frog   450 FNINADDGKITLAMELDRETNMWHNITVVATETRNHSQISRVPVAIKVLDVNDNAPEFATDYEAF 514

  Fly  1978 LPEHVPPRKVVE-ILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISS 2041
            |.|:..|.:::: :.|.|.||  ..||..|.:.|.|...:....:.|..||      :.::|::.
Frog   515 LCENGKPGQIIQTVSAIDKDD--PRNGHFFIYSLLPDMANNPNFTIKNNQD------NSLSVLAR 571

  Fly  2042 LRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTV-IIGDVNDNKMQPGSKDIFVYNYQGQSPDTP 2105
            ...|:|.:|:.|.:||:|.|:|:|.::.|||||: :.|..||..:|..:.:.:|         .|
Frog   572 HNGFNRLKQEVYFLPIIISDNGNPPLSSTSTLTIRVCGCSNDGVVQSCNAEAYV---------LP 627

  Fly  2106 IG 2107
            ||
Frog   628 IG 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637	28/87 (32%)
		Cadherin_repeat	1638..1741	CDD:206637	42/106 (40%)
		Cadherin_repeat	1762..1861	CDD:206637	21/112 (19%)
		Cadherin_repeat	1871..1966	CDD:206637	27/95 (28%)
		Cadherin_repeat	1974..2083	CDD:206637	34/110 (31%)
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
cdh8	XP_002935098.2	CA	98..176	CDD:214520	30/89 (34%)
		Cadherin_repeat	182..>262	CDD:206637	35/86 (41%)
		Cadherin_repeat	291..398	CDD:206637	24/124 (19%)
		Cadherin_repeat	406..503	CDD:206637	27/97 (28%)
		Cadherin_repeat	511..613	CDD:206637	33/109 (30%)
		Cadherin_C	656..801	CDD:366437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5175
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910