DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and dchs2

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:XP_012811431.2 Gene:dchs2 / 100485624 XenbaseID:XB-GENE-6048959 Length:3475 Species:Xenopus tropicalis


Alignment Length:3014 Identity:694/3014 - (23%)
Similarity:1128/3014 - (37%) Gaps:846/3014 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 LAIEETTFAGLSAENAARMLAGSPGDVEKSSLSHHSEMSLVLPHDTYPGFSIKKFKTHPVKINGS 99
            |.::.....||||:...|:      |:|..             :|..|.|....:.|     :.|
 Frog   851 LLVKAEDEGGLSAQAFVRV------DIEDI-------------NDNAPVFEPSTYVT-----SIS 891

  Fly   100 SHS-------------------GAAAYHMLDTDYSKYFTV-LEDGVVMTTADISPLVNRPVQLVV 144
            ||:                   |...|.:|..::|..||: ...|::...:.:|.|.:..|.|.|
 Frog   892 SHTQPGTEILNVMAIDRDEGLFGDVTYELLSGEHSSLFTIDSSTGIIYLISVLSHLEDSWVSLSV 956

  Fly   145 -------VEQTPNATNTHNL-------QLFVMHRNDMLRFSGSLLDASGEVRENQPAGTRVRGVP 195
                   :....|||.|.|:       .:|...|...:            :.|:.|.|:.|..|.
 Frog   957 AARDKGGLTSAVNATVTMNILKTATAPAIFEKSRYTFV------------IAEDVPKGSAVGTVK 1009

  Fly   196 LMQAFSGSILDEELATPKKVRYTIIDGNVDDAFALQERKANKNIQISAKSLVINGDDESGVWLVT 260
            ..         |.|.:.:.|.|.||.|||...|.:.                    .:.|: :.|
 Frog  1010 AR---------EPLNSLEPVSYRIISGNVHQMFTIH--------------------TQFGI-IRT 1044

  Fly   261 NRPLDREERAHYDLSVEASDVDGLDRTVSKIQITVLDENDNRPIFKSLDYKFAIAGQKSASMESN 325
            .:.||.|......|:|::........:.:::.:|:.|.|||.|:|.|.:.:.        |:..|
 Frog  1045 QKELDFESLPLVVLTVQSQLGSSSVFSSTQVNVTITDANDNPPVFSSENERI--------SVHQN 1101

  Fly   326 SSVTYQRFAIMGKVEATDAD---GDKIAYRLKSPSNVVIIVPQTGEIMLAGEPTSN--ELLIEVI 385
            :|.....:.    .:|||.|   ..:|:|.:.|.:..:.|:..|..::......|:  |.::.|:
 Frog  1102 TSPGTAIYI----AQATDLDSGFNGQISYSIASENQDLFIIDSTFGVLYLNATLSSVREHVLLVL 1162

  Fly   386 AHDLRYPSLVSAKPAKVLLE-FLAAEPVSFIMQHLEH-----DDINNHSHHREKRRVTRAVRPTK 444
            |.|..:|.|.|.....:::| ...:..:||.  :|.|     :.:..:||..:.:..||..:   
 Frog  1163 AEDYGHPVLSSLLTLTIIVEQNKQSNTLSFF--NLVHRTEISETLPINSHILQVKAYTRNTQ--- 1222

  Fly   445 RIEFTEADGDTEGKSVFQLEKETDKETFKIRDDNPWVTVETNGAVRVKKKWDYEELGPEKTIDFW 509
                     .|..:.::.|....|...|:|.....|:.        :::..|||:   .||.:..
 Frog  1223 ---------STSSEIMYSLSPTIDSAPFRIHQSTGWIF--------LRRSVDYEK---SKTHNLK 1267

  Fly   510 VIIT-------------------------------------------------------NMGHNA 519
            |:.|                                                       :.|:|.
 Frog  1268 VVATSGDREDQQTATASIIVKILDENDNSPSFDHATHFFTVNESPVPHGVIGSIQAFDRDSGNNG 1332

  Fly   520 GIKY--------------------------------------TDN--------QRVIILVKDVND 538
            .:.|                                      |||        ..|.|:|.|:||
 Frog  1333 QLSYFLLSEGNNFLISSKTGEIINCASLDHERKAHHELNVLVTDNGTPRRNATTTVYIIVADLND 1397

  Fly   539 EPPYFINRPLPMQAVVQLNAPPNTP--VFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGV 599
            ..|||.......|..|::......|  |.|:.|:|||..:|  :.||...|.:.|:|.::..:|.
 Frog  1398 NKPYFPQLASGKQLHVKVMEGQAEPMLVATVYAKDPDAGNNGTVVYFFASDESFGQFVINASTGE 1462

  Fly   600 VRTRGTDLFQLDMEYVLYVKAEDQNGKVDDRRFQSTPE------ERLSIVGG-KRAPQFYMPSYE 657
            :.|......:|..:|.|.|.|.|          |.||.      ..:.::.. |...:.......
 Frog  1463 IWTTKALSAKLRPQYGLTVTASD----------QGTPPLVEHTVVNIEVISAFKEKTKTVSKIKT 1517

  Fly   658 AEIPEN---QKKDSDIISIKAKSFADREIRYTLKAQGQGAGTFNIGPTSGIVKLAKELDFEDLRQ 719
            .::|||   .:|...:||.:.......::.|.| |..:..|.|.:...:|.|.:::.||||.:..
 Frog  1518 MKVPENTYPTQKIGSVISHEEAFLLSSKMHYRL-ANEENKGHFVVDSLTGDVYVSRHLDFETISY 1581

  Fly   720 PHVYSLIVTATEDSGGFSTSVDLTIRVTDVNDNAPKFELPDY-QAHNVDEDIPLGTSILRVKAMD 783
             :..|:.:...:.....:.||.|||.:.|.||:.|.|  ||: ....||||:|:||.:...||.|
 Frog  1582 -YGLSIDIQEIDKISPPNLSVFLTIYIEDTNDHRPLF--PDHIIVLGVDEDVPVGTLLYTFKAND 1643

  Fly   784 SD-SGSNAEIEYLVS------DDHFAVDSNGIIVNNKQLDADNNNAYYEFIVTAKDKGEPPKSGV 841
            .| |..|::|.|.::      :..|..:..|.:....:||.:...::. ..|||.|:........
 Frog  1644 KDGSLENSKIRYSLNTHGTGENPFFIHEWEGALTTANELDREMAESFV-LTVTATDQAANISHRR 1707

  Fly   842 AT---VRVYTKNKNDEEPKFSQQVYTP--NVDENAGPNTLVTTVVASDKD-GDNVRFGF-VGGGT 899
            .|   ||:..::.||..|   |.:..|  :|.|:|...:||..:||.|.| |.|.:.|| :..|.
 Frog  1708 CTSVIVRIVIQDINDNPP---QVLSLPVASVMEDAQIGSLVHRIVAKDPDEGRNGKIGFHIKEGN 1769

  Fly   900 SSGQFVIEDITGVIRLHNKAISLDKDKYELNVTAMDDGSCCVNGDQTIHTSTAVVVVFITDVNDN 964
            :...|::::.||.:.||::.....:|.|.|.:.|:|||...::..||:       .:.:.|||:.
 Frog  1770 AQQVFLLDETTGWLTLHSEIDREVQDHYILTILALDDGIPSLSVTQTL-------TISLIDVNNK 1827

  Fly   965 KPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGTKFTVDEETGEVS 1029
            .|.|.. ..|...|.|....|..||||.|.|.|.|.|..:.|.|:  |......|.::.||||:.
 Frog  1828 TPTFTQ-GLYEAAVPENQDPGLYVIKVAAVDYDLGNNSVLTYEIL--PGPAYGHFRINPETGELV 1889

  Fly  1030 TNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPP--LFDRQKYVENVKQDAS 1092
            |..|||||..|...:.|.||  |.|.|.|....:....|.|.||:.|  ||...:......||..
 Frog  1890 TTTVFDREQQDRFIIEVLVK--DGGSPPLSSTTAILCSILDENDHTPEVLFPDVEIRVPENQDLG 1952

  Fly  1093 IGTNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVLKKPLDGCYPRD---RYR 1154
            |   |..|.|:|:||.|||.:.:.:|   :.|...||.|...||.:...:.||    |:   .:.
 Frog  1953 I---IHTVLAADKDAGNNGRLHFQIT---DGNMGGYFAINNTSGQLWATRTLD----REDVSSFT 2007

  Fly  1155 LRVSASDKGTPASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGTVVTSVKASSGIEG- 1218
            :.|...|.|||..:....:.:.|:|.|:.||.:.||.|..: :||::.:|:.|..::||...|| 
 Frog  2008 ITVECHDLGTPHRSTIAKLRITVLDENDNPPTFPKSQYRTL-VREDLKIGSAVLKLQASDADEGL 2071

  Fly  1219 NPTVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQQL 1283
            |..:.|.|:..:..      .|.:.:      |..:|.....||.|...:|...: |.::.:...
 Frog  2072 NKEIIYSLIDDTQG------AFTVNR------TTGNIVTIRTLDREVKHQYVFRV-VASDCSLHN 2123

  Fly  1284 ASEATVYIM--LEDVNDEIPLFTEREQETVLEGEPIGTK-VTQVNAIDKDGTFPNNQVYYYIVDS 1345
            ...|||.::  :|||||..|:|||.....::..:.:..| :..|:|.|.|.......||..|..:
 Frog  2124 PKSATVKVLVYIEDVNDNSPVFTENPIHVLISPKVLENKTIANVHASDVDLGLNGTVVYNLIKSN 2188

  Fly  1346 PRNEGKEFFEINLQSGEI---------FTKTVFDREKKGAYALEVEARD-GAPSARPNSNGPNSV 1400
            |      ||.|..:.||:         |:.||          |:|:|.| |.|        ||:|
 Frog  2189 P------FFYITQEKGEVKLQMPLPAEFSSTV----------LQVQASDLGIP--------PNTV 2229

  Fly  1401 TKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSR-IRYEITSGNIGGAF 1464
            |..:.|.|... |....|..:.|||.:.||.:....|:||.|..|:.:.. |.|.:.||:..|||
 Frog  2230 TGLVIIDIQGL-DKEIAFVHNFYEAIILENSEAGTLVVTVKALYHNPNDEIIHYTVFSGDKKGAF 2293

  Fly  1465 AVKNMTGAIYV--AGALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQI 1527
            .:..:||.:.|  ...||:||..::.|.::|..:....|..|.:.::|.|||.|||::..|.:.:
 Frog  2294 NLNPITGDLMVKEPRLLDFETVNKFNLIISAESSQYTTYCRVTVFIQDDNDNAPVFDQLDYISFV 2358

  Fly  1528 TEEDDRNLPKRVLQVTATDGDKDRPQNIVY-FLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDR 1591
            :|....|  ..|:||.|.|||......|.| .::|.       .|:.|.::...|.:.....|||
 Frog  2359 SEGQPFN--TFVIQVFAADGDSGINGQIDYSIISGN-------ENNAFVLDSRHGILSTNVILDR 2414

  Fly  1592 DQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFP------------QGVYFGNV- 1643
            :.   :..:|.||.|.|.|.......:.|.|.:.|||||||..|            .|...|:: 
 Frog  2415 EI---KSSYRLTVQATDRGSPSCSSTSVVTVLILDINDNAPTIPPMNTVLIAEDAAPGYSIGSIS 2476

  Fly  1644 --------------TENGTAGMV--------VMTMT-AVDYDDPNE------------GSNARLV 1673
                          ||||..|:.        ::|:| ::||::.::            .:.|.|:
 Frog  2477 ANDVDLRPDLSYTFTENGNPGLKFAIDRYSGIITLTESLDYEESSQHCLRIQASDSVYHTEAELI 2541

  Fly  1674 YSI-----------------------EKNVI---------EEETGSPI----------FEIEPDT 1696
            ..:                       |.|..         :.|...||          |.|...:
 Frog  2542 IKVLDVNDNPPVFTQNIYKVALPELTESNTFITTVSATDQDSEIYGPITYKIISPLKGFVINTTS 2606

  Fly  1697 GVIKTAVCCLDRERTPDYSIQVVAMDGGG--LKGTGTASIRVKDINDMPPQFTKDEWFTEVDETD 1759
            |.:.|.:......::.:..|.:||||.|.  |..|...|:.:.|:|:..|.|::|.::..|.|  
 Frog  2607 GSVYTDMPLGKENKSTEIQILIVAMDNGSPPLTSTAMLSVTILDVNNYAPTFSEDIYYVNVSE-- 2669

  Fly  1760 GTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADKFTMVRNNDG----------TGSLKIVQP 1814
             .||....:||:|..|.|.:.|  ..:||.|..|.:...:......          ||.|.|.||
 Frog  2670 -DALVGDTVLTLTAMDLDWSPK--NALIDFSIIGGNAHNLFYLESSEVLSHIPFIVTGKLIINQP 2731

  Fly  1815 LDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTK 1879
            ||:|   .::..|..|.|:::|....|..     :.:::.:.|.|||.|.|..:...|||.|...
 Frog  2732 LDFE---VASAHRLDIFVSNQGFPPLNSS-----ATIIINILDSNDNPPLFSNSEYHVSVREHYP 2788

  Fly  1880 VGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAIN-QNGSVTIQRSLDREVVPRHQVKILAI 1943
            :.:.:....|||.|.|..:.::|||...:| :..|.|: |||:||:.:.||.|...::.:.:.|.
 Frog  2789 LKSTIIIISATDSDTGENADITYSIVSGND-ENVFTIDAQNGTVTLVQPLDYEETMKYSLTLQAR 2852

  Fly  1944 D-DGSPPKTATATLTVIVQDINDNAPKFLKDYRPV-LPEHVP---PRKVVEILATDDDDRSKSNG 2003
            | .||....|.|.|::.|.|.||.|||||...:.. :.|:||   |  |..:.|.|         
 Frog  2853 DGHGSKRNVAFALLSITVLDENDFAPKFLFQSQSCNIYENVPFFSP--VCSVNAID--------- 2906

  Fly  2004 PPFQFRLDPSADDIIRASFKVE----QDQK--------GANGDGMAVISSLRSFDREQQKEYMIP 2056
                  ||.....|:  ||.::    .||:        ...||    |.:....|.|.|:.:.:.
 Frog  2907 ------LDSGQYGIL--SFSIQSSCFNDQQHPATFLIDSLTGD----IYTKHRIDYEMQERHCLV 2959

  Fly  2057 IVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSP-DTP--------IGRVYVY 2112
            :.:||...    .::.:.|.|....:::.||    :|   ||.|.. |.|        ||:|...
 Frog  2960 VQVKDRSE----SSACVLVYIDIEGEDEFQP----VF---YQNQYLFDLPEENIGGQEIGKVGAL 3013

  Fly  2113 DLDDWDLPDKKFYWEAMEHPR--FKLDEDSGMVTM-------RAGTREGRYHLRFKV------YD 2162
            |.|: .|.....|:  :|.|.  |.::..|||:.:       |:.||:....:.|.|      :|
 Frog  3014 DNDE-GLDGVVHYF--LEKPSQFFSINMTSGMIYLTRTVHKKRSNTRKNDEFIEFHVKAHSPKFD 3075

  Fly  2163 RKHTQTDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDKLAD 2227
            .|.....:..|::..:.:.|   |:::..:.::                                
 Frog  3076 SKSAMCTVRVNISSALEDYP---VMSANILSIT-------------------------------- 3105

  Fly  2228 LLNTERENVDIFSVQLKRKHPPLTDVRFSAHGSPYYKPVRLNGIVLMHREEIEKDVGINITMVGI 2292
                       ||:..         |.|      ....:.|.||:|.|:   :|:|         
 Frog  3106 -----------FSISF---------VVF------LLLAISLIGIILRHK---KKEV--------- 3132

  Fly  2293 DECLYENQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFTKPESCRTTPCHN 2357
                               ::|                        ||.::...|     .|..|
 Frog  3133 -------------------VNP------------------------CGIKDLAIP-----APDSN 3149

  Fly  2358 GGRC----------VDTRFGPHCSCPVGY--------TGPRCQQTTRSFRGNGWAWYPPLEMCDE 2404
            |..|          :.|...|.....:|.        |||:|:.:..|..|:...     |..::
 Frog  3150 GKDCKSKECPKYDHIKTSISPDTPEWLGLVDIREKKDTGPKCRNSDSSGHGSTEG-----ETAED 3209

  Fly  2405 SHLSL--EFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTK 2467
            ..:.:  |:..||..|               :::||..:...:.|.||                .
 Frog  3210 EEIKMINEYPIRKESG---------------SVLSDRASRVPDSGIPR----------------D 3243

  Fly  2468 KTLDDGEWHRIDLFWDTESIRMVV------DFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNE 2526
            ..|...|....||...|||...:|      |.|.|..|.:.|                 :|..| 
 Frog  3244 SDLLSCESDETDLVLRTESTESIVILRHGKDECNSNNIHDKE-----------------LPHTN- 3290

  Fly  2527 YLNVNAPLQVGGLYREQFDQSLY---FWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAG 2588
                ::||      ::..|..|:   .:.::||.           |.|:...||....|...:.|
 Frog  3291 ----HSPL------KKSKDTPLHNRMDYIFVPTP-----------HESRYGSLASLVASDEDLRG 3334

  Fly  2589 CPQTEEVCA-----QTETTARCWEHGNCVGSLSEARCH---------------------CRPGWT 2627
            ....:.:.:     |..::..|     .:|.|.:.:.|                     .:||..
 Frog  3335 SYNWDYLLSWEPRFQALSSVFC-----DIGKLKDEKMHRHGLPKQKKPFIFPPPLITSVAQPGIR 3394

  Fly  2628 GPACNIPTIPTTFKAQSYVKYALS 2651
            ...   |.:||....|:::||..|
 Frog  3395 AVP---PRMPTIMSGQTFLKYPRS 3415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637 25/122 (20%)
Cadherin_repeat 337..396 CDD:206637 16/63 (25%)
E_set 449..541 CDD:298831 25/192 (13%)
Cadherin_repeat 549..>625 CDD:206637 23/79 (29%)
Cadherin_repeat 655..752 CDD:206637 25/99 (25%)
Cadherin_repeat 765..853 CDD:206637 26/97 (27%)
Cadherin_repeat 862..964 CDD:206637 32/105 (30%)
Cadherin_repeat 973..1074 CDD:206637 38/100 (38%)
Cadherin_repeat 1083..1166 CDD:206637 26/85 (31%)
Cadherin_repeat <1219..1298 CDD:206637 17/80 (21%)
Cadherin_repeat 1310..1414 CDD:206637 29/114 (25%)
Cadherin_repeat 1423..1514 CDD:206637 30/93 (32%)
Cadherin_repeat 1522..1630 CDD:206637 30/108 (28%)
Cadherin_repeat 1638..1741 CDD:206637 31/182 (17%)
Cadherin_repeat 1762..1861 CDD:206637 28/108 (26%)
Cadherin_repeat 1871..1966 CDD:206637 33/96 (34%)
Cadherin_repeat 1974..2083 CDD:206637 24/124 (19%)
EGF 2350..2380 CDD:278437 9/47 (19%)
LamG 2385..2570 CDD:238058 33/195 (17%)
EGF_2 <2605..2631 CDD:285248 6/46 (13%)
Laminin_G_2 2665..2800 CDD:280389
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
dchs2XP_012811431.2 Cadherin_repeat 42..137 CDD:206637
CA <347..387 CDD:214520
Cadherin_repeat 394..488 CDD:206637
Cadherin_repeat <600..661 CDD:206637
Cadherin_repeat 672..769 CDD:206637
Cadherin_repeat 778..877 CDD:206637 8/44 (18%)
Cadherin_repeat 885..977 CDD:206637 21/96 (22%)
Cadherin_repeat 991..1085 CDD:206637 25/135 (19%)
Cadherin_repeat 1095..1182 CDD:206637 20/98 (20%)
Cadherin_repeat 1198..1295 CDD:206637 17/119 (14%)
Cadherin_repeat 1305..1398 CDD:206637 11/92 (12%)
Cadherin_repeat 1412..1502 CDD:206637 25/99 (25%)
Cadherin_repeat 1517..1613 CDD:206637 25/97 (26%)
Cadherin_repeat 1626..1723 CDD:206637 27/97 (28%)
Cadherin_repeat 1732..1825 CDD:206637 29/99 (29%)
Cadherin_repeat 1836..1932 CDD:206637 38/99 (38%)
Cadherin_repeat 1942..2036 CDD:206637 30/103 (29%)
Cadherin_repeat 2044..2141 CDD:206637 27/110 (25%)
Cadherin_repeat 2149..2238 CDD:206637 28/112 (25%)
Cadherin_repeat 2251..2345 CDD:206637 30/93 (32%)
Cadherin_repeat 2354..2450 CDD:206637 30/107 (28%)
Cadherin_repeat 2459..2550 CDD:206637 13/90 (14%)
Cadherin_repeat 2558..2652 CDD:206637 19/93 (20%)
Cadherin_repeat 2662..2770 CDD:206637 30/120 (25%)
Cadherin_repeat 2778..2875 CDD:206637 32/97 (33%)
Cadherin_repeat 2888..2983 CDD:206637 24/121 (20%)
Cadherin_repeat 2992..3087 CDD:206637 23/97 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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