Protein Alignment Sytalpha and SYT12

DIOPT Version :9

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_024304534.1
• Gene: SYT12 / 91683
• HGNCID: 18381
• Length: 487
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 128/499 - (25%)
• Similarity: 209/499 - (41%)
• Gaps: 127/499 - (25%)

  Fly     1 MTTHSLSAGE--------MDIVIREEDISLA------QIGVYA--SVSFLVVSAVGA-ALYTTCS 48
            |.|.:...||        |.:.:.|..:|:.      ::||||  :::.|.::||.. .|:|:.|
Human    49 MKTKAPPVGEVTVTAADIMAVDVAEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGS 113

  Fly    49 -------KRYRLNWFEQNLLESANEKDEDQQREALVAGAVGYNVDNVNEVPRGKYSSGNAGNLSP 106
                   ..|...:.:|...||..|..|                   ..||  .:::..|....|
Human   114 FPSPSPFPNYDYRYLQQKYGESCAEARE-------------------KRVP--AWNAQRASTRGP 157

  Fly   107 TSLKSEDNDPAFWVPASVTSTAAIQQQVSNTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDK 171
            .|.|.                       |.:.|::....|..|.|:
Human   158 PSRKG-----------------------SLSIEDTFESISELGPLE------------------- 180

  Fly   172 HVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLNEVR------------GNLHV 224
                          .|..:||..... ||.:|.|..      |||.:.            |.:.|
Human   181 --------------LMGRELDLAPYG-TLRKSQSAD------SLNSISSVSNTFGQDFTLGQVEV 224

  Fly   225 SLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVF 289
            |:.||.....|||.:::.::|..|:.:.....:.:|.||||::....:||.:...:..|||:|..
Human   225 SMEYDTASHTLNVAVMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSI 289

  Fly   290 EVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSEQ-LKLWTPLSSASAQDMKVD-LG 352
            .:....::::::...::..|...|:|..|..:|.|:.|||..| ...|..|..   |:...| :|
Human   290 PLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQD---QNKAADAVG 351

  Fly   353 DIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNP 417
            :|::||:|||:||||.||::||:||...:| :.::||:|||.|| ..|:|:.|:||.|:|...||
Human   352 EILLSLSYLPTAERLTVVVVKAKNLIWTND-KTTADPFVKVYLL-QDGRKMSKKKTAVKRDDPNP 414

  Fly   418 VYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIGNS 461
            |:|||:.|.|....|::..|..||......|..:.:|..:||.|
Human   415 VFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPS 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	33/135 (24%)
		C2B_Synaptotagmin	352..488	CDD:175975	49/110 (45%)
SYT12	XP_024304534.1	C2	218..329	CDD:326325	28/110 (25%)
		C2B_Synaptotagmin-12	350..485	CDD:176051	49/111 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820