Protein Alignment Sytalpha and SYT7

DIOPT Version :10

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_011543637.1
• Gene: SYT7 / 9066
• HGNCID: 11514
• Length: 692
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 143/532 - (26%)
• Similarity: 243/532 - (45%)
• Gaps: 76/532 - (14%)

  Fly     6 LSAGEMDIVIREEDISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNLLESANEKDED 70
            |:||:::: ...||.:|:......|:.    |:.|...........|....:|.|.:....:...
Human   188 LAAGKLNL-SNFEDSTLSTATTLESIP----SSTGEPKCQRPRTLMRQQSLQQPLSQHQRGRQPS 247

  Fly    71 Q--------QREALVAGAVGYNVDNVNEVPRGKYSSG-NAGNLSPTSLKSEDNDPAFW------- 119
            |        |.:|.:|.|.|   .|.....||:...| :||:....:.....::|..|
Human   248 QPTTSQSLGQLQAHMASAPG---PNPRAYGRGQARQGTSAGSKYRAAGGRSRSNPGSWDHVVGQI 309

  Fly   120 ---------------VPASVTSTAAIQQQVSNTTEESAPPTS-----------PTGSLKSNTLSY 158
                           |..|:....:.|...:|..:...|.|.           |.|....||...
Human   310 RNRGLDMKSFLEGRMVVLSLVLGLSEQDDFANIPDLQNPGTQQNQNAQGDKRLPAGGKAVNTAPV 374

  Fly   159 CSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLH 223
            ...|  |...||:.       :.|| ||::..::....:|.:....|:....:.....|..|.:.
Human   375 PGQT--PHDESDRR-------TEPR-SSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQ 429

  Fly   224 VSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFV 288
            .|:||:.....|.|::::||.|..:.||||:||:.|:.||||||:..:|::.::.|||.::|.|:
Human   430 FSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFL 494

  Fly   289 FEVTAGVIDKRTVEILLY----DFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPLSSASAQDMKV 349
            ||   |...::.|:.:||    |:|.:||:..||...:.|..:||::....|..|...|  |...
Human   495 FE---GFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCS--DGSG 554

  Fly   350 DLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGT 414
            ..|::::||.|.|||..::|.:||||||:.: |...:|||||||.|:.. .|:::|:||...:..
Human   555 SRGELLLSLCYNPSANSIIVNIIKARNLKAM-DIGGTSDPYVKVWLMYK-DKRVEKKKTVTMKRN 617

  Fly   415 LNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIG--NSPEVRTEEKIFFEEVFR 477
            |||::||:.|||:..|.|:...:..||:....|..::::|:..:.  :.|   .|.|.:.:.:.|
Human   618 LNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGP---GEVKHWKDMIAR 679

  Fly   478 AKNATAQWVPLQ 489
            .:...|||..|:
Human   680 PRQPVAQWHQLK 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	45/126 (36%)
		C2B_Synaptotagmin	352..488	CDD:175975	48/137 (35%)
SYT7	XP_011543637.1	PHA03307	<149..>316	CDD:223039	26/135 (19%)
		C2A_Synaptotagmin-7	424..548	CDD:176032	45/126 (36%)
		C2B_Synaptotagmin-7	556..691	CDD:176050	48/139 (35%)