Protein Alignment Sytalpha and SYT3

DIOPT Version :9

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001153800.1
• Gene: SYT3 / 84258
• HGNCID: 11511
• Length: 590
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 161/559 - (28%)
• Similarity: 252/559 - (45%)
• Gaps: 97/559 - (17%)

  Fly    17 EEDISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNLLESANEKDEDQQREAL----- 76
            :.|||::.:.|.  |:|..:..:|.:|:.:    ::|.|...          .|:...|:
Human    48 DADISVSLLSVI--VTFCGIVLLGVSLFVS----WKLCWVPW----------RDKGGSAVGGGPL 96

  Fly    77 ---------VAGAVGYNVDNV------NEVPRGKYSSGNAGN-------LSPTSLKSEDN-DPAF 118
                     :||.||....::      :.:..|.:...:|.:       |.|.||...|. :|::
Human    97 RKDLGPGVGLAGLVGGGGHHLAAGLGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPSY 161

  Fly   119 W----VPASVTSTAAIQQQVSNTTEE------------SAPPTS---PTGSLKSNTLSYCSTTSV 164
            .    .|.:..:..|...:.|.|:.|            ..||:.   |:........|...||..
Human   162 LDMDSYPEAAAAAVAAGVKPSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRY 226

  Fly   165 P-IARSDKHVVLAMHP-----SRPRVSSM-------NAKLDHTKIDMTLY--------RSHSQPK 208
            | :.|......|...|     .||....:       .||| ..:|...||        ||...|.
Human   227 PALPRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKL-IGQIKPELYQGTGPGGRRSGGGPG 290

  Fly   209 TINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTR 273
            : .........|.:..:|.|......|.||:|:|.:|..:..:|.:|||.|:.||||:|..:||:
Human   291 S-GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTK 354

  Fly   274 IHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLAN-LDLSEQ---LK 334
            :|::||||||:|.|.|.|....:.:|.:...:||||.:|||..||  ::.|.| |:|:||   ..
Human   355 VHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIG--QVVLDNLLELAEQPPDRP 417

  Fly   335 LWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPG 399
            ||..:....::  |.|||::..||.|||:|.||.|.:|||.||:.: |....||||||.:|:..
Human   418 LWRDIVEGGSE--KADLGELNFSLCYLPTAGRLTVTIIKASNLKAM-DLTGFSDPYVKASLISE- 478

  Fly   400 GKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIGNSPEV 464
            |:::|||||.:::.||||.|||||.||||.|:::|..|...||....:|.:|::|...:|.....
Human   479 GRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAAD 543

  Fly   465 RTEEKIFFEEVFRAKNATAQWVPLQEPANNLATSAKSSK 503
            ....:.:.|.:...:.....|..|.| ...:.:..|.||
Human   544 PHGREHWAEMLANPRKPVEHWHQLVE-EKTVTSFTKGSK 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	50/126 (40%)
		C2B_Synaptotagmin	352..488	CDD:175975	53/135 (39%)
SYT3	NP_001153800.1	Cysteine motif. /evidence=ECO:0000250|UniProtKB:O35681	10..34
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..220		14/76 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..260		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..295		5/22 (23%)
		C2A_Synaptotagmin-1-5-6-9-10	299..424	CDD:176031	50/126 (40%)
		C2B_Synaptotagmin-3-5-6-9-10	433..567	CDD:176048	53/135 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820