DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and Sytl3

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_113572.1	Gene:	Sytl3 / 83672	MGIID:	1933367	Length:	607	Species:	Mus musculus

Alignment Length:	382	Identity:	84/382 - (21%)
Similarity:	154/382 - (40%)	Gaps:	88/382 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 EESAPPTSPT------GSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKID 197
            ::..||:|||      |.|:..:|...::|...:...|                 ||
Mouse   264 KQDTPPSSPTHSAVFSGGLRHGSLISINSTCTEMGNFD-----------------NA-------- 303

  Fly   198 MTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNL-QPRQFSGTADPYAKVR 261
                               .|.|.:..::.|......|.:.:...:|| ...:.....:||.|..
Mouse   304 -------------------NVTGEIEFAIHYCVKSCSLEICIKTCKNLAYGEEKKRKCNPYVKTY 349

  Fly   262 LLPDKKNFW--QTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHL 324
            ||||:.:..  :||:.|.||:|.|:|...::|..|.:..|.:::.::.....:|.|.:|...|.|
Mouse   350 LLPDRSSQGKRKTRVQKNTLDPTFEETLKYQVDPGQLMTRRLQVSVWHLGTLARRVFLGEVILPL 414

  Fly   325 ANLDLSE---QLKLWTPLSSASAQDMKVDL----GDIMV-SLAYLPSAER--------------- 366
            |..|..:   |...|.|| .|.|:..:.::    |::.| :...||:..|
Mouse   415 AMWDFKDSTAQNARWYPL-RAKAEKYEENIPQNNGELAVRAKLVLPAGPRKPQEAQEGQLALNGQ 478

  Fly   367 LMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFD-VAKE 430
            |.:|::.|:||.:..|...:|  :||..|..|..:|::. |:.|.:....|.:..:..|: |:..
Mouse   479 LCLVVLGAKNLPVRSDGTLNS--FVKGCLTLPNQQKLRV-KSPVLKKQACPQWKHSFVFNGVSSS 540

  Fly   431 TLKNCVLEFTVVHDGLLGSSE-ILGRTLIGNS------PEVRTEEKIFFEEVFRAKN 480
            .|:...||.||....:.|.:: :||...:|:.      |:..::.|:.:..|..:.|
Mouse   541 QLRQSTLELTVWDQAIFGMNDRLLGEARLGSKGGAAGCPDSGSQSKLQWHRVLSSPN 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	35/128 (27%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	35/153 (23%)
Sytl3	NP_113572.1	PHD_SF	14..123	CDD:389947
		FYVE_like_SF	60..108	CDD:333710
		DUF4195	<200..>292	CDD:372746	8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..279		5/14 (36%)
		C2	306..433	CDD:387358	34/127 (27%)
		C2B_SLP_1-2-3-4	447..607	CDD:175987	35/154 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910