Protein Alignment Sytalpha and Sytl2

DIOPT Version :9

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001355807.1
• Gene: Sytl2 / 83671
• MGIID: 1933366
• Length: 2153
• Species: Mus musculus
• Alignment Length: 541
• Identity: 124/541 - (22%)
• Similarity: 204/541 - (37%)
• Gaps: 143/541 - (26%)

  Fly    73 REALVAGAVGYNVDNVNEVPRG----KYSSGNAG----NLSPTSLKSEDNDP---------AFWV 120
            ||..:..|..|......:.|..    ::|.||..    |...||...|::.|         |..:
Mouse  1646 REVKLVLATPYKRQEEEQGPEACSEYEFSDGNTSSNRENWRNTSSSEEEHSPVLKTLERRAARKL 1710

  Fly   121 PA----SVTSTAAIQQQVSN-------------------TTEESAPPTSPTGSLKSNTLSYCS-- 160
            |:    .:.|.::.|.:|.|                   .|.|..|..|...||..|..|:..
Mouse  1711 PSKSLEDIPSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVPSLPDNQFSHPDKL 1775

  Fly   161 ---TTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLN------ 216
               :.|||....|:        |..|.:...::..:     .|.|....|.::..:|.:
Mouse  1776 KRMSKSVPAFLQDE--------SDDRETDTASESSY-----QLRRYKKSPSSLTNLSSSSGMTSL 1827

  Fly   217 ------------------EVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQF-SGTADPYAKVRL 262
                              ||:|::..:|.|......|:|.:.:.::|..... ...:|||.|..|
Mouse  1828 SSASGSVMSVYSGDFGNLEVKGSVQFALDYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKTYL 1892

  Fly   263 LPDKKNFW--QTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLA 325
            ||||....  :|.:.|:|||||::|...:::....:..:.:.:.::..|.:.|:..:|..:|.|.
Mouse  1893 LPDKGKMGKKKTLVVKKTLNPVYNEILRYKIERQFLKTQKLNLSVWHRDTFKRNSFLGEVELDLE 1957

  Fly   326 NLD----LSEQLKLWTPLSSASAQDMKVDL-----GDIMVSLAYLPS-----------------A 364
            ..|    .::||| |.||...:|   .|.|     |::.::|.|:|.                 .
Mouse  1958 TWDWDSKQNKQLK-WYPLKRKTA---PVALETENRGEMKLALQYVPEPSPGKKLPTTGEVHIWVK 2018

  Fly   365 ERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFD-VA 428
            |.|.:.|::..:|       ||   :||.|:| |...:..::||.....|.|||:|..:.:| ..
Mouse  2019 ECLDLPLLRGSHL-------NS---FVKCTIL-PDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFR 2072

  Fly   429 KETLKNCVLEFTVVHDGLLGSSEILGRTLIG------NSPEV-----RTEEKIFFEEVFRAKNAT 482
            .|.|....:|.| |.|....:::.||...||      ...||     .:||...:|::..:.|.
Mouse  2073 PEDLMEACVELT-VWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNT- 2135

  Fly   483 AQWVPLQEPANNLATSAKSSK 503
              ||....|...|.. ||.||
Mouse  2136 --WVEATLPLRMLLI-AKLSK 2153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	36/129 (28%)
		C2B_Synaptotagmin	352..488	CDD:175975	41/164 (25%)
Sytl2	NP_001355807.1	PHD_SF	5..>41	CDD:419867
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..98
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..289
		C2A_SLP-1_2	1848..1975	CDD:176039	34/127 (27%)
		C2B_SLP_1-2-3-4	1988..2144	CDD:175987	42/170 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810