DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and syt3

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001186849.1	Gene:	syt3 / 779540	XenbaseID:	XB-GENE-956378	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	517	Identity:	140/517 - (27%)
Similarity:	238/517 - (46%)	Gaps:	89/517 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IREEDISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNLLESANEKDEDQQREALVAG 79
            ||..|:|::.:.|.  |:|..:..:|.:|:.:    ::|.|.......|:..:.:|....    |
Frog    48 IRNTDVSVSLLSVI--VTFCGIVLLGVSLFVS----WKLCWIPWRDKGSSQTQRKDHGHH----G 102

  Fly    80 AVGYN------VDNVN---EVPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTSTAAI----- 130
            .:.::      .|.|.   |:|...|.  :..:...|::|.....|...|.:.....:.|
Frog   103 HLHHSHYGDLLADRVELGPEMPERSYL--DMDSYPETNIKISQTSPDIPVDSQPPKESQIPYAQS 165

  Fly   131 QQQVSNTTEESAPP--TSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDH 193
            .|||:|....:..|  .:|.....:|..|     ::|            .|...::||.:
Frog   166 HQQVANIAPANVAPANVAPANVAPANRYS-----TLP------------RPMTQQLSSPD----- 208

  Fly   194 TKIDMTLYRSHSQPKTINPVSLNEVR---------------------GNLHVSLGYDPVGGLLNV 237
                   :..|...|.....|:.:::                     |.:...|.|......|.|
Frog   209 -------FSGHVDEKPEQATSIGQIKPELYKQRSADAEMKKQEATSCGRISFILRYAYNSEQLVV 266

  Fly   238 RLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVE 302
            ::|:|..|..:..:|.:|||.|:.||||:|..:||::|::||||:|:|.|.|.|....:..|.:.
Frog   267 KILKALELPAKDANGFSDPYVKMYLLPDRKKKFQTKVHRKTLNPIFNETFHFNVPFNELQNRKLH 331

  Fly   303 ILLYDFDAYSRHVCIGGSKLHLANL----DLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPS 363
            ..:||||.:|||..||  ::.|.||    :.:::..:|..:..||::  |.|||:|..||.|||:
Frog   332 FSIYDFDRFSRHDLIG--QVVLDNLLEFSNATDETPIWRDILEASSE--KADLGEINFSLCYLPT 392

  Fly   364 AERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVA 428
            |.||...:|||.||:.: |....||||||.:|:.. |:::|||||.:::.||||.|||||.||:.
Frog   393 AGRLTATIIKATNLKAM-DLTGFSDPYVKASLICE-GRRLKKRKTSIKKNTLNPTYNEALVFDIP 455

  Fly   429 KETLKNCVLEFTVVHDGLLGSSEILGRTLIGNSPEVRTEEKIFFEEVFRAKNATAQWVPLQE 490
            .|.:.:..|...|:....:|.:|::|...:|:..:::..|. :.|.:...:.....|..|.|
Frog   456 NENMDHVSLTIAVMDYDCIGHNEVIGMCRVGSDADMQGREH-WNEMLANPRKPIEHWHQLVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	44/147 (30%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	50/135 (37%)
syt3	NP_001186849.1	C2A_Synaptotagmin-1-5-6-9-10	248..372	CDD:176031	44/125 (35%)
syt3	NP_001186849.1	C2B_Synaptotagmin-3-5-6-9-10	381..514	CDD:176048	50/135 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920