DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and SYT5

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_003171.2	Gene:	SYT5 / 6861	HGNCID:	11513	Length:	386	Species:	Homo sapiens

Alignment Length:	275	Identity:	103/275 - (37%)
Similarity:	166/275 - (60%)	Gaps:	10/275 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFD 284
            |.|..||.||...|.|.|.:|:|..|......|::|||.:|.|||||:..::|::|::||||.|.
Human   110 GRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFG 174

  Fly   285 EQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPLSSASAQDMKV 349
            |.|.|:|....:..|.:.:.:||||.:||:..||..::.::::||...::.|..|.:|..::.:
Human   175 ETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQE- 238

  Fly   350 DLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGT 414
            .||||..||.|:|:|.:|.|::::|:||:.: |....|||||||.|| .||||::|:||.:::.|
Human   239 KLGDICFSLRYVPTAGKLTVIVLEAKNLKKM-DVGGLSDPYVKVHLL-QGGKKVRKKKTTIKKNT 301

  Fly   415 LNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIG---NSPEVRTEEKIFFEEVF 476
            |||.||||.:|:|..:.::...:|.||:....||.:|.:||..:|   ....:|.    :.:.:.
Human   302 LNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRH----WADMLA 362

  Fly   477 RAKNATAQWVPLQEP 491
            ..:...|||..|:.|
Human   363 NPRRPIAQWHSLRPP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	46/120 (38%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	53/138 (38%)
SYT5	NP_003171.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2A_Synaptotagmin-1-5-6-9-10	109..231	CDD:176031	46/120 (38%)
		C2	240..374	CDD:387358	54/139 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820