Protein Alignment Sytalpha and SYT5

DIOPT Version :10

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_003171.2
• Gene: SYT5 / 6861
• HGNCID: 11513
• Length: 386
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 103/275 - (37%)
• Similarity: 166/275 - (60%)
• Gaps: 10/275 - (3%)

  Fly   220 GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFD 284
            |.|..||.||...|.|.|.:|:|..|......|::|||.:|.|||||:..::|::|::||||.|.
Human   110 GRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFG 174

  Fly   285 EQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPLSSASAQDMKV 349
            |.|.|:|....:..|.:.:.:||||.:||:..||..::.::::||...::.|..|.:|..::.:
Human   175 ETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQE- 238

  Fly   350 DLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGT 414
            .||||..||.|:|:|.:|.|::::|:||:.: |....|||||||.|| .||||::|:||.:::.|
Human   239 KLGDICFSLRYVPTAGKLTVIVLEAKNLKKM-DVGGLSDPYVKVHLL-QGGKKVRKKKTTIKKNT 301

  Fly   415 LNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIG---NSPEVRTEEKIFFEEVF 476
            |||.||||.:|:|..:.::...:|.||:....||.:|.:||..:|   ....:|.    :.:.:.
Human   302 LNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRH----WADMLA 362

  Fly   477 RAKNATAQWVPLQEP 491
            ..:...|||..|:.|
Human   363 NPRRPIAQWHSLRPP 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	46/120 (38%)
		C2B_Synaptotagmin	352..488	CDD:175975	53/138 (38%)
SYT5	NP_003171.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Syt1_2_N	<21..76	CDD:409247
		C2A_Synaptotagmin-1-5-6-9-10	109..231	CDD:176031	46/120 (38%)
		C2	240..374	CDD:472691	54/139 (39%)