Protein Alignment Sytalpha and SYT4

DIOPT Version :10

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_065834.1
• Gene: SYT4 / 6860
• HGNCID: 11512
• Length: 425
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 118/418 - (28%)
• Similarity: 191/418 - (45%)
• Gaps: 78/418 - (18%)

  Fly   104 LSPTSLKSEDND---------PAFWVPASVTSTAAIQQQVSNTTEESAPPTSPTGSLKSNTLSYC 159
            ::|.:...|:.|         .||.:..:|:..|.|..|..::.....||......||...:...
Human     1 MAPITTSREEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRKSSKSNKTPPYKFVHVLKGVDIYPE 65

  Fly   160 STTS-VPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKT-------------- 209
            :..| ......||:.|    .::|.|...:..||..|.|:    :.:.|||
Human    66 NLNSKKKFGADDKNEV----KNKPAVPKNSLHLDLEKRDL----NGNFPKTNLKPGSPSDLENAT 122

  Fly   210 -----------INPVSL-----------NEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPR-QFS 251
                       ::|.||           .|..|.|..||.|:.......|.:.||:.|... :.|
Human   123 PKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQS 187

  Fly   252 GTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGV----IDKRTVEILLYDFDAYS 312
            .|:|||.|:.:||:||:..:||:.::||:|.|||.|.|   .|:    |.:..:...:..||.:|
Human   188 MTSDPYIKMTILPEKKHKVKTRVLRKTLDPAFDETFTF---YGIPYTQIQELALHFTILSFDRFS 249

  Fly   313 RHVCIGGSKLHLANLDLSEQLKLWTPLSSASAQDMKVDL------GDIMVSLAYLPSAERLMVVL 371
            |...||...:.|:.::|||...|      .:.:.:|.::      |::::||.|..:...|.||:
Human   250 RDDIIGEVLIPLSGIELSEGKML------MNREIIKRNVRKSSGRGELLISLCYQSTTNTLTVVV 308

  Fly   372 IKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCV 436
            :|||:|. ..|....|||||||.|. ...|:|.|:||.|::.|.|.|:||...||:..|.|::..
Human   309 LKARHLP-KSDVSGLSDPYVKVNLY-HAKKRISKKKTHVKKCTPNAVFNELFVFDIPCEGLEDIS 371

  Fly   437 LEFTVVHDGLLGS-SEILGRTLIGNSPE 463
            :||.|: |...|| :|::|:.::|.:.|
Human   372 VEFLVL-DSERGSRNEVIGQLVLGAAAE 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	42/127 (33%)
		C2B_Synaptotagmin	352..488	CDD:175975	45/113 (40%)
SYT4	NP_065834.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..93		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..147		3/19 (16%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	42/134 (31%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	45/114 (39%)