Protein Alignment Sytalpha and Doc2a

DIOPT Version :10

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_075226.1
• Gene: Doc2a / 65031
• RGDID: 620518
• Length: 403
• Species: Rattus norvegicus
• Alignment Length: 298
• Identity: 91/298 - (30%)
• Similarity: 143/298 - (47%)
• Gaps: 37/298 - (12%)

  Fly   220 GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPD--KKNFWQTRIHKRTLNPV 282
            |.|...|.||....:|:.|:|.|:.|:|..|:|.||||.|:.|||.  |.|..:|:..:.|||||
  Rat    94 GTLEFDLLYDQASCMLHCRILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPV 158

  Fly   283 FDEQFVFE-VTAGVIDKRTVEILLYDFDAYSRHVCIG-----------GSKLHLANLDLSEQLKL 335
            ::|:..:. :|...|..:.:.|.:.|.|..|.:..||           ..|.|. |:.|..|:.|
  Rat   159 WNEELTYSGITDDDITHKVLRISVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHF-NICLERQVPL 222

  Fly   336 WTPLSSASA-----------------QDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDA 383
            .:|.|.::|                 ..:..:.|.|::||:|......|:|.:::..:|..: |.
  Rat   223 PSPSSMSAALRGISCYLKELEQAEQGPGLLEERGRILLSLSYSSRRHGLLVGIVRCAHLAAM-DV 286

  Fly   384 RNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLG 448
            ...|||||| |.|.|...|..|.||.|::.||||.:||...:::...||....||.||....:..
  Rat   287 NGYSDPYVK-TYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEMELSTLATKTLEVTVWDYDIGK 350

  Fly   449 SSEILGRTLIGNSPEVRTE-EKIFFEEVFRAKNATAQW 485
            |::.:|...:|  |..|.| :|.:.:.:.:...|..:|
  Rat   351 SNDFIGGVSLG--PGARGEAQKHWRDCLHQPDTAVERW 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	45/134 (34%)
		C2B_Synaptotagmin	352..488	CDD:175975	44/135 (33%)
Doc2a	NP_075226.1	Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250	1..92
		C2A_Rabphilin_Doc2	93..216	CDD:176000	41/122 (34%)
		Interaction with UNC13D. /evidence=ECO:0000250	218..403		49/173 (28%)
		C2B_Rabphilin_Doc2	257..389	CDD:176030	43/134 (32%)