DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and Syt4

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_113881.1	Gene:	Syt4 / 64440	RGDID:	68397	Length:	425	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	130/494 - (26%)
Similarity:	211/494 - (42%)	Gaps:	130/494 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTHSLSAGEMDIVIREEDISLAQIGVYASVSFLVVSAVGAALYTTCSKR---------YR---- 52
            :||..:...|:..|          :|:::  :|.:|..|....:..|.:|         |:
  Rat     4 ITTSRVEFDEIPTV----------VGIFS--AFGLVFTVSLFAWICCQRRSAKSNKTPPYKFVHV 56

  Fly    53 ---LNWFEQNLLE----SANEKDEDQQREALVAGAVGYNVDNVNEVPRGKYSSGNAGNLSPTSLK 110
               ::.:.:||..    ..::|.|.:::.||...::..:::.       :..:||....:|.:..
  Rat    57 LKGVDIYPENLSSKKKFGGDDKSEAKRKAALPNLSLHLDLEK-------RDLNGNFPKTNPKAGS 114

  Fly   111 SEDNDPAFWVPASVTSTAAIQQQVSNTTEESAPPT-----SPTGSLKSNTLSYCSTTSVPIARSD 170
            |.|                    :.|.|.:..|.|     ||. ||||:|    |.||     .:
  Rat   115 SSD--------------------LENVTPKLFPETEKEAVSPE-SLKSST----SLTS-----EE 149

  Fly   171 KHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLL 235
            |                                            .|..|.|.:||.|:......
  Rat   150 K--------------------------------------------QEKLGTLFLSLEYNFEKKAF 170

  Fly   236 NVRLLEAQNLQPR-QFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGV---- 295
            .|.:.|||.|... :.|.|:|||.|:.:||:||:..:||:.::||:|||||.|.|   .||
  Rat   171 VVNIKEAQGLPAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPVFDETFTF---YGVPYPH 232

  Fly   296 IDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAY 360
            |.:.::...:..||.:||...||...:.|:.::||:...|.|..............|:::|||.|
  Rat   233 IQELSLHFTVLSFDRFSRDDVIGEVLVPLSGIELSDGKMLMTREIIKRNAKKSSGRGELLVSLCY 297

  Fly   361 LPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAF 425
            ..:...|.||::|||:|. ..|....|||||||.|. ...|:|.|:||.|::.|.|.|:||...|
  Rat   298 QSTTNTLTVVVLKARHLP-KSDVSGLSDPYVKVNLY-HAKKRISKKKTHVKKCTPNAVFNELFVF 360

  Fly   426 DVAKETLKNCVLEFTVVHDGLLGS-SEILGRTLIGNSPE 463
            |:..|:|:...:||.|: |...|| :|::||.::|.:.|
  Rat   361 DIPCESLEEISVEFLVL-DSERGSRNEVIGRLVLGATAE 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	45/127 (35%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	47/113 (42%)
Syt4	NP_113881.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..121		5/38 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..147		10/25 (40%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	45/128 (35%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	47/114 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820