DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and Syt11

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_006232810.1	Gene:	Syt11 / 60568	RGDID:	62042	Length:	430	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	131/495 - (26%)
Similarity:	216/495 - (43%)	Gaps:	100/495 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DISLAQIGVYASVSFLVVSAVGAALYTTC----SKRYR------------LNWFEQNLLESANEK 67
            |:|....|:..:...:|..:|...::|.|    .|:::            ::.:.:.|   :|:|
  Rat    12 DVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQAEKKHKTPPYKFIHMLKGISIYPETL---SNKK 73

  Fly    68 DEDQQREALVAGAVGYNVDNVNEVPRGKYSSGNAGNL---SPTSLKSEDNDPAFWVPASVTSTAA 129
                            .:..|.....|.:.....|||   :.:.|.|.|.||....|||......
  Rat    74 ----------------KIIKVRRDKDGSHRESGRGNLLVNAESGLLSHDRDPRGPSPASCIDQLP 122

  Fly   130 IQQQVSNTTEESAPPTSPT-GSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDH 193
            |::....  |..:|.||.| |..|..:                       ||.|....|...|
  Rat   123 IKRDYGE--ELRSPMTSLTPGESKPTS-----------------------PSSPEEDVMLGSL-- 160

  Fly   194 TKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYA 258
                 |....::.||....|::.|..| |.|..|                     |..| :|||.
  Rat   161 -----TFSVDYNFPKKALVVTIQEAHG-LPVMDG---------------------QTQG-SDPYI 197

  Fly   259 KVRLLPDKKNFWQTRIHKRTLNPVFDEQFVF-EVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKL 322
            |:.:||||::..:||:.::||:|||||.|.| .:....:....:..|:..||.:||...||...:
  Rat   198 KMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMV 262

  Fly   323 HLANLDLSE-QLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNS 386
            .||.:|.|. :::|...:...:.|.. :..|::.|||:|.|.|:|:.||::|||:|..:|....|
  Rat   263 PLAGVDPSTGKVQLTRDIIKRNIQKC-ISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLS 326

  Fly   387 SDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSE 451
            .:|||||.:. .|.|:|.|:||.|::.||||::||:..:|:..:.|.:..:||.|:.......:|
  Rat   327 GNPYVKVNVY-YGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNE 390

  Fly   452 ILGRTLIGNSPEVRTEEKIFFEEVFRA-KNATAQWVPLQE 490
            ::||.::| :..|.|.....:.||..: :...|:|..|.|
  Rat   391 VVGRLILG-AHSVTTSGAEHWREVCESPRKPVAKWHSLSE 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	37/124 (30%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	49/136 (36%)
Syt11	XP_006232810.1	C2A_Synaptotagmin-4-11	157..282	CDD:176034	43/154 (28%)
Syt11	XP_006232810.1	C2B_Synaptotagmin-4	291..428	CDD:176049	49/138 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820