DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and Syt10

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_113854.1	Gene:	Syt10 / 60567	RGDID:	62041	Length:	523	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	154/515 - (29%)
Similarity:	245/515 - (47%)	Gaps:	87/515 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNW--------------FEQNLLESANEKDE 69
            |||::.:.|..|...|.:..|...::      ::|.|              ..|::..:..|..|
  Rat    51 DISVSLLAVVVSFCGLALLVVSLFVF------WKLCWPCWKSKLVAPNVSTLPQSISSAPTEVFE 109

  Fly    70 DQQREALVAGAVGYNVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTSTAAIQQQV 134
            .::::.:          ..||.|..|       .:.| ::|.....|.  :||.|.:  |:::.:
  Rat   110 TEEKKEV----------EENEKPAPK-------AIEP-AIKISHTSPD--IPAEVQT--ALKEHL 152

  Fly   135 SNTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMN----------- 188
            ..........|.||.|.:.|:..             :|:     |.:..|||::
  Rat   153 IKHARVQRQTTDPTSSSRHNSFR-------------RHL-----PRQMNVSSVDFSMGTEPVLQR 199

  Fly   189 --AKLDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFS 251
              .:....:|...||:..|.....|.....:..|.|:.:|.||....||.|::::|.:|..:.|:
  Rat   200 GETRTSIGRIKPELYKQKSVDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFT 264

  Fly   252 GTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVC 316
            ||:|||.|:.||||:|..:|||:|::||||:|||.|.|.|....:..|.:...:||||.:|||..
  Rat   265 GTSDPYVKIYLLPDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDM 329

  Fly   317 IGGSKLHLANL----DLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNL 377
            ||  ::.|.||    |||.:..:|..:..|:.:  .:|||:||.||.|||:|.|:.:.:||.|||
  Rat   330 IG--EVILDNLFEVSDLSREATVWKDIHCATTE--SIDLGEIMFSLCYLPTAGRMTLTVIKCRNL 390

  Fly   378 RIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVV 442
            :.: |...||||||||:|:.. |:::|||||..::.|||||||||:.||:..|.:....|...|:
  Rat   391 KAM-DITGSSDPYVKVSLMCE-GRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVM 453

  Fly   443 HDGLLGSSEILGRTLIGNSPEVRTEEKIFFEEVFRAKNATAQWVPLQE-PANNLATSAKS 501
            ....:|.:|::|....|...|....:. :.|.:...:.....|.||.| |..  |||..|
  Rat   454 DYDRVGHNEVIGVCRTGLDAEGLGRDH-WNEMLAYHRKPITHWHPLLELPGR--ATSFDS 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	53/126 (42%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	52/135 (39%)
Syt10	NP_113854.1	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	13..35
		C2A_Synaptotagmin-1-5-6-9-10	231..356	CDD:176031	53/126 (42%)
		C2B_Synaptotagmin-3-5-6-9-10	365..498	CDD:176048	52/135 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.780