DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and Syt7

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_006231127.1	Gene:	Syt7 / 59267	RGDID:	62013	Length:	687	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	144/537 - (26%)
Similarity:	245/537 - (45%)	Gaps:	76/537 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTHSLSAGEMDIVIREEDISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNLLESAN 65
            |....|:||:::: ...||.:|:......|:.    |:.|...........|....:|.|.::..
  Rat   178 MVQSHLAAGKLNL-SNFEDSTLSTATTLESIP----SSAGEPKCQRPRTLMRQQSLQQPLSQNQR 237

  Fly    66 EKDEDQ--------QREALVAGAVGYNVDNVNEVPRGKYSSG-NAGNLSPTSLKSEDNDPAFW-- 119
            .:...|        |.:|..|.|.|   .|.....||:...| :||:....:.....::|..|
  Rat   238 GRQPSQPTTSQSLGQLQAHAASAPG---SNPRAYGRGQARQGTSAGSKYRAAGGRSRSNPGSWDH 299

  Fly   120 --------------------VPASVTSTAAIQQQVSNTTEESAPPTS-----------PTGSLKS 153
                                |..|:....:.|...:|..:...|.|.           |.|....
  Rat   300 VVGQIRNRGLDMKSFLEGRMVVLSLVLGLSEQDDFANIPDLQNPGTQQNQNAQGDKRLPAGGKAV 364

  Fly   154 NTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLNEV 218
            ||......|  |...||:.       :.|| ||::..::....:|.:....|:....:.....|.
  Rat   365 NTAPVPGQT--PHDESDRR-------TEPR-SSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSREN 419

  Fly   219 RGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVF 283
            .|.:..|:||:.....|.|::::||.|..:.||||:||:.|:.||||||:..:|::.::.|||.:
  Rat   420 LGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHW 484

  Fly   284 DEQFVFEVTAGVIDKRTVEILLY----DFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPLSSASA 344
            :|.|:||   |...::.|:.:||    |:|.:||:..||...:.|..:||::....|..|...|
  Rat   485 NETFLFE---GFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCS- 545

  Fly   345 QDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTG 409
             |.....|::::||.|.|||..::|.:||||||:.: |...:|||||||.|:.. .|:::|:||.
  Rat   546 -DGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAM-DIGGTSDPYVKVWLMYK-DKRVEKKKTV 607

  Fly   410 VQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIG--NSPEVRTEEKIFF 472
            .::..|||::||:.|||:..|.|:...:..||:....|..::::|:..:.  :.|   .|.|.:.
  Rat   608 TKKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGP---GEVKHWK 669

  Fly   473 EEVFRAKNATAQWVPLQ 489
            :.:.|.:...|||..|:
  Rat   670 DMIARPRQPVAQWHQLK 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	45/126 (36%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	48/137 (35%)
Syt7	XP_006231127.1	C2A_Synaptotagmin-7	419..543	CDD:176032	45/126 (36%)
Syt7	XP_006231127.1	C2B_Synaptotagmin-7	551..686	CDD:176050	48/139 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820