DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and sytl5

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_686619.6	Gene:	sytl5 / 558324	ZFINID:	ZDB-GENE-070912-424	Length:	692	Species:	Danio rerio

Alignment Length:	437	Identity:	108/437 - (24%)
Similarity:	181/437 - (41%)	Gaps:	97/437 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 GNLSPTSLKSEDNDPAFW----------VPASVTSTAAIQQQVSNTTEESAPPTSPTGSLKSNTL 156
            |..|.:|::|.|:.|...          .|:...|.|::....|.:..:.:.|..  |..:...:
Zfish   223 GAESVSSIQSSDSVPEKMADGRRQTDSSTPSIAVSRASLSSDRSRSEVDLSNPGE--GLSEDPLI 285

  Fly   157 SYCSTTSVP---IARSDKHV--VLAMH----------------PSRPR----VSSMNAKLDHTKI 196
            |.|  .|||   ...||:.:  ||:.|                |:..|    ::..::..|.|.|
Zfish   286 SRC--RSVPGLNDGDSDEDIDAVLSAHYKTNRSVCSAQSMSSTPASERKWGFLNVPDSDADTTSI 348

  Fly   197 D--MTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNL----QPRQFSGTAD 255
            :  |::|.......::      .|.|.:.:::.|....|.|||.:.|.:.|    :.||   ..|
Zfish   349 NSLMSVYSETGDYGSV------RVSGEILLNISYSYKTGALNVLVRECRCLATGDERRQ---RTD 404

  Fly   256 PYAKVRLLPDK--KNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIG 318
            .|.|..|||||  ::..:|.|...:.||||:|...:.|:...::.||:::.::..|.:..:..:|
Zfish   405 AYVKTYLLPDKSRQSKRKTSIKSNSTNPVFNENLRYVVSHSQLETRTLQVSVWHHDRFGHNNFLG 469

  Fly   319 GSKLHLANLDLSEQLKLWTPLSSASAQDMKVD-----LGDIMVSLAYLPSAER------------ 366
            .::|...:.:...|::.|..|......|. ||     .|::.|.|.|:| |||
Zfish   470 ETELTFDSWEFDTQIEEWFALQPRIESDY-VDSVMHYKGELTVVLKYIP-AERNVSLPLDQVQVK 532

  Fly   367 -----------------LMVVLIK-ARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRG 413
                             ::.:|:| |:||..|..  .||||:||..|| |..||..|.||.|.:.
Zfish   533 KGFLKGKKKTITLPKGGMVELLVKEAKNLTAVKG--GSSDPFVKGYLL-PDDKKSTKHKTAVVKR 594

  Fly   414 TLNPVYNEALAF-DVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIG 459
            ::||.:|....: .:....|.:..||.||.......|:..||...:|
Zfish   595 SVNPRWNHTFTYCGLQHSDLDSVCLELTVWDREPFASNVFLGGVRLG 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	35/128 (27%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	41/139 (29%)
sytl5	XP_686619.6	PHD_SF	13..124	CDD:304600
		C2A_SLP-4_5	367..491	CDD:175995	33/126 (26%)
		C2B_SLP_1-2-3-4	506..683	CDD:175987	41/140 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810