DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and Syt10

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_061273.1	Gene:	Syt10 / 54526	MGIID:	1859546	Length:	523	Species:	Mus musculus

Alignment Length:	509	Identity:	158/509 - (31%)
Similarity:	248/509 - (48%)	Gaps:	75/509 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DISLAQIGV---YASVSFLVVSA-VGAALYTTCSKRY----RLNWFEQNLLESANEKDEDQQREA 75
            |||::.:.|   :..::.||||. |...|...|.|..    .|:...|::..:..|..|.::::.
Mouse    51 DISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKLVAPNLSVLPQSISSAPTEVFETEEKKE 115

  Fly    76 LVAGAVGYNVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTSTAAIQQQVSNTTEE 140
            :          ..||.|..|       .:.| ::|.....|.  :||.|.:  |:::.:......
Mouse   116 V----------EENEKPAPK-------AIEP-AIKISHTSPD--IPAEVQT--ALKEHLIKHARV 158

  Fly   141 SAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMN-------------AKLD 192
            ....|.||.|.:.|:..             :|:     |.:..|||::             .:..
Mouse   159 QRQTTEPTSSSRHNSFR-------------RHL-----PRQMNVSSVDFSVGTEPILQRGETRTS 205

  Fly   193 HTKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPY 257
            ..:|...||:..|.....|.....:..|.|:.:|.||....||.|::::|.:|..:.|:||:|||
Mouse   206 IGRIKPELYKQKSVDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPY 270

  Fly   258 AKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKL 322
            .|:.||||:|..:|||:|::||||:|||.|.|.|....:..|.:...:||||.:|||..||  ::
Mouse   271 VKIYLLPDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIG--EV 333

  Fly   323 HLANL----DLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDA 383
            .|.||    |||.:..:|..:..|:.:  .:|||:||.||.|||:|.|:.:.:||.|||:.: |.
Mouse   334 ILDNLFEVSDLSREATVWKDIHCATTE--SIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAM-DI 395

  Fly   384 RNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLG 448
            ..||||||||:|:.. |:::|||||..::.|||||||||:.||:..|.:....|...|:....:|
Mouse   396 TGSSDPYVKVSLMCE-GRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVMDYDRVG 459

  Fly   449 SSEILGRTLIGNSPEVRTEEKIFFEEVFRAKNATAQWVPLQE-PANNLATSAKS 501
            .:|::|....|...|....:. :.|.:...:.....|.||.| |..  |||..|
Mouse   460 HNEVIGVCRTGLDAEGLGRDH-WNEMLAYHRKPITHWHPLLELPGR--ATSFDS 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	53/126 (42%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	52/135 (39%)
Syt10	NP_061273.1	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	13..35
		C2A_Synaptotagmin-1-5-6-9-10	231..356	CDD:176031	53/126 (42%)
		C2B_Synaptotagmin-3-5-6-9-10	365..498	CDD:176048	52/135 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.780