DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and Syt6

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_006501767.1	Gene:	Syt6 / 54524	MGIID:	1859544	Length:	529	Species:	Mus musculus

Alignment Length:	479	Identity:	147/479 - (30%)
Similarity:	233/479 - (48%)	Gaps:	83/479 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EEDISLAQIGVYASVSFLVVSAVGAALYTT-CSKRYRLNWFEQNLLESANEKDEDQQREALVAGA 80
            |:..|.|..|...|:..:||...|.||... ....::|.|......|:::....:...|.|
Mouse    46 EQSPSAADSGTSVSLLAVVVIVCGVALVAVFLFLFWKLCWMPWRKKEASSPSSANPASETL---- 106

  Fly    81 VGYNVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTSTAAIQQQVSNTTEESAPPT 145
                           .|..:.||::.   |.:|.....::.|:|        ::|:|:.:.  |.
Mouse   107 ---------------QSPSSRGNMAD---KLKDPSALGFLEAAV--------KISHTSPDI--PA 143

  Fly   146 SPTGSLKSNTLSYCS---TTSVPIARSDKHVVLAMH-PSRPRVSSMNAKLDHTKIDMTLYRSHSQ 206
            ....|:|.:.:.:..   .|:.| |.|.:|.....| |.:..|||::            |.:...
Mouse   144 EVQMSVKEHIMRHTKLQRQTTEP-ASSTRHTSFKRHLPRQMHVSSVD------------YGNELP 195

  Fly   207 PKTI-NPVSLNEVR----------------------GNLHVSLGYDPVGGLLNVRLLEAQNLQPR 248
            |... .|.|:..::                      |.::.||.||.....|.||:|:|.:|..:
Mouse   196 PAAAEQPTSIGRIKPELYKQKSVDGDDAKSEAAKSCGKINFSLRYDYESETLIVRILKAFDLPAK 260

  Fly   249 QFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSR 313
            .|.|::|||.|:.||||:|...|||:|::||||.|||.|.|.|....:..|.:.:.::|||.:||
Mouse   261 DFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSR 325

  Fly   314 HVCIGGSKLHLANL----DLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKA 374
            |..||  ::.|.||    |||.:..:|..:..|:::  .||||:||.||.|||:|.||.:.:||.
Mouse   326 HDMIG--EVILDNLFEASDLSRETSIWKDIQYATSE--SVDLGEIMFSLCYLPTAGRLTLTVIKC 386

  Fly   375 RNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEF 439
            |||:.: |....|||||||:|| ..|:::||:||.:::.||||:||||:.||:..|.:....|..
Mouse   387 RNLKAM-DITGYSDPYVKVSLL-CDGRRLKKKKTTIKKNTLNPIYNEAIIFDIPPENMDQVSLLI 449

  Fly   440 TVVHDGLLGSSEILGRTLIGNSPE 463
            :|:....:|.:||:|...:|.:.|
Mouse   450 SVMDYDRVGHNEIIGVCRVGINAE 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	52/148 (35%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	50/112 (45%)
Syt6	XP_006501767.1	C2A_Synaptotagmin-1-5-6-9-10	231..355	CDD:176031	52/125 (42%)
Syt6	XP_006501767.1	C2B_Synaptotagmin-3-5-6-9-10	364..497	CDD:176048	50/112 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820