DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and Syt5

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001347350.1	Gene:	Syt5 / 53420	MGIID:	1926368	Length:	386	Species:	Mus musculus

Alignment Length:	328	Identity:	113/328 - (34%)
Similarity:	182/328 - (55%)	Gaps:	18/328 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPV 231
            |::..|:.......|..:..:..:::.      |.||.|.|.  ..||.....|.|..||.||..
Mouse    65 AQAQVHLQEVKELGRSYIDKVQPEIEE------LDRSPSMPG--QQVSDKHQLGRLQYSLDYDFQ 121

  Fly   232 GGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVI 296
            .|.|.|.:|:||.|......|::|||..|.|||||:...:|::|::||||.|.|.|.|:|....:
Mouse   122 TGQLLVGILQAQGLAALDLGGSSDPYVSVYLLPDKRRRHETKVHRQTLNPHFGETFAFKVPYVEL 186

  Fly   297 DKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYL 361
            ..|.:.:.:||||.:||:..||..::.:::::|...::.|..|..|..::.: .||||..||.|:
Mouse   187 GGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVNLGRPVQAWRELQVAPKEEQE-KLGDICFSLRYV 250

  Fly   362 PSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFD 426
            |:|.:|.|::::|:||:.: |....|||||||.|| .||||::|:||.:::.||||.||||.:|:
Mouse   251 PTAGKLTVIVLEAKNLKKM-DVGGLSDPYVKVHLL-QGGKKVRKKKTTIKKNTLNPYYNEAFSFE 313

  Fly   427 VAKETLKNCVLEFTVVHDGLLGSSEILGRTLIG---NSPEVRTEEKIFFEEVFRAKNATAQWVPL 488
            |..:.::...:|.||:....||.:|.:||..:|   ....:|.    :.:.:...:...|||..|
Mouse   314 VPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAVGGAGLRH----WADMLANPRRPIAQWHSL 374

  Fly   489 QEP 491
            :.|
Mouse   375 RPP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	46/122 (38%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	53/138 (38%)
Syt5	NP_001347350.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Herpes_gI	<3..64	CDD:332941
		C2	108..230	CDD:326325	45/121 (37%)
		C2	240..374	CDD:326325	54/139 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820