DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and Sytl3

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_006227950.1	Gene:	Sytl3 / 499017	RGDID:	1561992	Length:	609	Species:	Rattus norvegicus

Alignment Length:	423	Identity:	90/423 - (21%)
Similarity:	167/423 - (39%)	Gaps:	103/423 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 KSEDNDPAFWVPASVTSTAAI---------QQQVSNTTEESAPPTSPT------GSLKSNTLSYC 159
            :...:|.|..|.:..|||..|         :...|...::..||:|||      |.|:..:|...
  Rat   228 RRSQSDTAVNVTSRKTSTPDILKAFHQEDPRHPPSPVLKQDTPPSSPTHSTVFSGGLRHGSLISV 292

  Fly   160 STTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLHV 224
            ::|...:...|                 ||                           .|.|.:..
  Rat   293 NSTCTEMGNFD-----------------NA---------------------------NVTGEIEF 313

  Fly   225 SLGYDPVGGLLNVRLLEAQNL----QPRQFSGTADPYAKVRLLPDKKNFW--QTRIHKRTLNPVF 283
            ::.|......|.:.:...:||    ..|:   ..:||.|..||||:.:..  :||:.|.||:|.|
  Rat   314 AIHYCVNSHSLEICIKTCKNLAYGEDKRR---KCNPYVKTYLLPDRSSQGKRKTRVQKNTLDPTF 375

  Fly   284 DEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDL---SEQLKLWTPLSSASAQ 345
            :|...::|....:..|.:::.::.....:|.|.:|...|.||..|.   :.|...|.|| .|.|:
  Rat   376 EETLKYQVDPAQLATRRLQVSVWHLGTLARRVFLGEVILPLATWDFEGSAAQNARWYPL-RAKAE 439

  Fly   346 DMKVDL----GDIMV-SLAYLPSAERLM---------------VVLIKARNLRIVDDARNSSDPY 390
            ..:.::    |::.| :...||...|::               :|::.|:||.:..|...:|  :
  Rat   440 KYEENIPQTNGELAVRAKLVLPVGPRMLQEAQEDQLALNGQLCLVVLGAKNLPVRSDGTLNS--F 502

  Fly   391 VKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFD-VAKETLKNCVLEFTVVHDGLLGSSE-IL 453
            ||..|..|..:|::. |:.|.:....|.:..:..|: |:...|:...||.||....:.|.:: :|
  Rat   503 VKGCLTLPDQQKLRV-KSPVLKKQACPQWKHSFVFNGVSSSQLRQSTLELTVWDQAMFGMNDRLL 566

  Fly   454 GRTLIGNS------PEVRTEEKIFFEEVFRAKN 480
            |...:|:.      .:..::.|:.:::|..:.|
  Rat   567 GEAKLGSKGGAPGCTDSCSQSKLQWQKVLSSPN 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	35/131 (27%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	33/153 (22%)
Sytl3	XP_006227950.1	PHD_SF	14..123	CDD:419867
		FYVE_like_SF	60..108	CDD:333710
		C2	308..435	CDD:417471	34/130 (26%)
		C2B_SLP_1-2-3-4	449..609	CDD:175987	33/154 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810