DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and sytl2

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_012812257.2	Gene:	sytl2 / 493264	XenbaseID:	XB-GENE-945155	Length:	2036	Species:	Xenopus tropicalis

Alignment Length:	558	Identity:	126/558 - (22%)
Similarity:	216/558 - (38%)	Gaps:	149/558 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EQNLLESANEKDED----QQREALVAGAVGYNVDNVNEVPRGKYSSG----NAGNL--------S 105
            ::|.|:...|..|.    |::...:..|..|.|.:.|.   |...||    ::|||        |
Frog  1517 KENNLDRLTEPQEQGSTTQRKPQDLYFAARYEVLDKNS---GSDQSGSVTESSGNLLYKKPESES 1578

  Fly   106 PTSLKSEDNDPAFWVPASVTSTAAIQQQVSNTTEESAP-PTSPTGSLKSNTLSYCSTTSVP---- 165
            |.:.|....||...:..|.....|:::   ::|:...| |.......|||.    ...:||
Frog  1579 PDASKRNSIDPKQGIEESDPILRALKR---SSTKTLPPLPVQEVSLEKSNQ----DDITVPKEDR 1636

  Fly   166 -----IARSDKHVVLAMHPSRP----RVSS-----MNAKLDHTKID------MTLYRSHSQPKTI 210
                 ..|:||.|....|.|.|    |:|.     :|...|..:.|      ..|.|....|.::
Frog  1637 DHTYEEVRADKVVPERSHFSDPEKLKRLSQSVPSFLNDDTDGRETDSASESSFQLGRHKKSPSSL 1701

  Fly   211 NPVSLN------------------------EVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQF- 250
            ..:|.:                        :::||:..:|.|             |.|||..|.
Frog  1702 TNLSGSSGMASLSSVSGSVMSIYSGDFGNVDIKGNIQFALDY-------------ADNLQEFQVF 1753

  Fly   251 -------------SGTADPYAKVRLLPDKKNFW--QTRIHKRTLNPVFDEQFVFEVTAGVIDKRT 300
                         ...:|||.|..|||:|....  :|.:.|:|||||:::...::::...:..:|
Frog  1754 VSQCKDLAAADVKKQRSDPYVKAYLLPEKAKMGKRKTGVKKKTLNPVYNDVLRYKISKNALLSQT 1818

  Fly   301 VEILLYDFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPL---SSASAQDMKVDLGDIMVSLAYLP 362
            :.:.::..|...|:..:|...::||:.|.|.:...|.||   :.|:...:: :.|::.::|.|:|
Frog  1819 LNLSVWHHDVLGRNSFLGEVDVNLASWDWSNKQMNWYPLQPRTPAAGIGLE-NRGEMKLALKYVP 1882

  Fly   363 SA---------ERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPV 418
            .|         ..:.:.|.:..||.::  ..|..:.::|.|:|....:|.:::...|.: |.||.
Frog  1883 EAFTGAKNAGTGEVHIWLKECTNLPML--RGNKINSFIKCTILPDTSRKSRQKTRAVDK-TPNPY 1944

  Fly   419 YNEALAFD-VAKETLKNCVLEFTV-VHDGLLGSSEILGRTLIG----------------NSPEVR 465
            :|..:.:| ..||.||...:|.|| .|:.|  ::..||...||                |:.|..
Frog  1945 FNHTMVYDGFRKEDLKEACVELTVWDHNKL--TNHFLGGLRIGLGTGKSYGTPVDWMDSNAAEAT 2007

  Fly   466 TEEKIFFEEVFRAKNATAQWVPLQEPANNLATSAKSSK 503
            |.||:.        .:...||....|...| ..||.:|
Frog  2008 TWEKMI--------TSPDTWVEAILPLRML-KMAKMAK 2036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	35/141 (25%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	39/162 (24%)
sytl2	XP_012812257.2	PHD_SF	5..>44	CDD:419867
		C2A_SLP-1_2	1734..1858	CDD:176039	34/136 (25%)
		C2B_SLP_1-2-3-4	1871..2027	CDD:175987	40/168 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910