DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and syt9b

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001003985.1	Gene:	syt9b / 445476	ZFINID:	ZDB-GENE-040822-6	Length:	517	Species:	Danio rerio

Alignment Length:	502	Identity:	157/502 - (31%)
Similarity:	246/502 - (49%)	Gaps:	83/502 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EEDISLAQIGVYASVSFLVVSAVGAALY-TTCSKRYRLNW--FEQNLLESANEKDEDQQREALVA 78
            :.|:|:       |:..|:|:..|.||: .:....::|.|  :....|.|.  ||:..:::.::|
Zfish    48 DSDVSV-------SLLSLLVTTCGLALFAVSLFVSWKLFWVPWRDRFLPSL--KDQQGEQQPVLA 103

  Fly    79 GAVGYNVDNVNEVPRGKYSSGNAGNLSPTS-LKSEDNDPAFWVPASVTS-------TAAIQQQVS 135
            ...|..    .|.........||..:.|.| :|.....|...:.|...:       .|.:|:||
Zfish   104 EVEGLE----REYSEDFEKDPNAPLVLPESAMKISHTSPDIQLEAQTKAKELNHIHIARVQRQV- 163

  Fly   136 NTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHT------ 194
                     |.||.|::.|:          |.|.       |:.|.|..:....:...:
Zfish   164 ---------TEPTSSVRHNS----------IRRQ-------MNVSNPDFNMAQFQRQESITGPGL 202

  Fly   195 -KIDMTLYRSHSQPKTINPVSLNEVR-----GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGT 253
             :|...||:..|       |..::.|     |.||..:.||.....|.|::..||:|..:.|:||
Zfish   203 GRIKPELYKQRS-------VDTDDGRRADSCGRLHFIIKYDCDLEQLIVKIHRAQDLPAKDFTGT 260

  Fly   254 ADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIG 318
            :|||.|:.||||:|...||::|::||||:|||.|:|.|..|.:..|.:...:||||.:|||..||
Zfish   261 SDPYVKIYLLPDRKTKHQTKVHRKTLNPIFDEVFLFPVAYGELPTRKLHFSVYDFDRFSRHDVIG 325

  Fly   319 GSKLHLANL----DLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRI 379
              ::.:.|.    |..::.:|...:...||.:  |||||:|.||.|||:|.||.:.:||||||:.
Zfish   326 --QVVVDNFLDLPDFPQETRLCRDILYVSADN--VDLGDLMFSLCYLPTAGRLTITIIKARNLKA 386

  Fly   380 VDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHD 444
            : |...:|||||||:|: ..|:::|||||..:|.|||||||||:.|||..|.:....|...|:..
Zfish   387 M-DITGASDPYVKVSLM-CDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQISLLIAVMDY 449

  Fly   445 GLLGSSEILGRTLIGN-SPEVRTEEKIFFEEVFRAKNATAQWVPLQE 490
            ..:|.:|::|...:|| :|.:..:.  :.|.:...:...|:|..|.|
Zfish   450 DRVGHNEVIGICHVGNRAPSLGRDH--WNEMLTYPRKPIARWHQLVE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	50/131 (38%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	57/136 (42%)
syt9b	NP_001003985.1	C2	226..350	CDD:301316	49/125 (39%)
syt9b	NP_001003985.1	C2B_Synaptotagmin-3-5-6-9-10	359..492	CDD:176048	57/136 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.780