DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and Syt4

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	129/515 - (25%)
Similarity:	219/515 - (42%)	Gaps:	84/515 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EEDISLAQI--GVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNLLESANEKD---EDQQREAL 76
            ||.|..|.:  .:..::..|..:||.:::...|:::.||    :|..:|.::..   :..:|...
  Fly     3 EEYIPDASVMDTIVPAILGLTAAAVLSSVACICARQMRL----RNKKQSQHDASFPFQPTRRPTA 63

  Fly    77 VAGAVGYNVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTSTAAIQQQVSNTTEES 141
            |....|.....:.:.|            |||..|    ......|....||:.|.|.....:||.
  Fly    64 VRSPSGQPPHYLKKSP------------SPTGGK----QMGLLSPMQDQSTSPIAQPNVKYSEEG 112

  Fly   142 APPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQ 206
            ..|.........|.|:......:      ||             |::..|.|:.::  ...:.|.
  Fly   113 DGPAQHAEQQNGNQLTVVDGNGL------KH-------------SLHNSLHHSPVE--TIANGSV 156

  Fly   207 PKTINPVSLNEVR-----------GNLHVSLGYDPVGGLLNVRLLEAQNLQ-----------PRQ 249
            ..|::..||...:           |.::..|.|......|.|.::..:.|.           |..
  Fly   157 TITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTG 221

  Fly   250 FSG----TADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVF-EVTAGVIDKRTVEILLYDFD 309
            .:|    ..|||.|::|||||::..:||:.:.|.|||:||.|.| .:....:...::..::..||
  Fly   222 MNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFD 286

  Fly   310 AYSRHVCIGGSKLHLANLDL----SEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVV 370
            .|||...||.....|.::::    .|.|.:...:...|.:......|::::||.:.|:|.||.||
  Fly   287 RYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSLKIRAQGRGELLISLCWQPAAGRLTVV 351

  Fly   371 LIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDV-----AKE 430
            |:|||||..: |....:|||||:.|| ..|::|.|:||.|::.||:||:||:.|||:     |..
  Fly   352 LLKARNLPRM-DVTGLADPYVKIYLL-YNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGA 414

  Fly   431 TLKNCVLEFTVVHDGLLGSSEILGRTLIGNSPEVRTEEKIFFEEVFRAKNATAQWVPLQE 490
            :|:...||..::....:..:|::||..:|......|....:.|.....:...|:|..|.|
  Fly   415 SLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKLNE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	37/153 (24%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	50/140 (36%)
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	37/142 (26%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	50/142 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468168
Domainoid	1	1.000	68	1.000	Domainoid score	I3464
eggNOG	1	0.900	-	-		E1_KOG1028
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850