Protein Alignment Sytalpha and Sytl2

DIOPT Version :10

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001101962.2
• Gene: Sytl2 / 361604
• RGDID: 1307647
• Length: 2155
• Species: Rattus norvegicus
• Alignment Length: 578
• Identity: 133/578 - (23%)
• Similarity: 221/578 - (38%)
• Gaps: 162/578 - (28%)

  Fly    32 SFLVVSAVGAALYTTCSKRYRLNWFEQNLLESANEKDEDQQREALVAGAVGYNVDNVNEVPRGKY 96
            |.:::...|.|..|:..|         :.|.:|.::.|.:|         |....:.:|...|..
  Rat  1634 SIVLLETKGKATETSTVK---------SELATAYKRQEKEQ---------GPEACSESEFSDGNT 1680

  Fly    97 SSGNAGNLSPTSLKSEDNDP---------AFWVPA----SVTSTAAIQQQVSN------------ 136
            || |..:...||...|::.|         |..:|:    .:.|.::.|.:|.|
  Rat  1681 SS-NRESWRNTSSSEEEHSPVLKTLERRAARKIPSKSLEDIPSDSSNQAKVDNLPEELVRSAEDD 1744

  Fly   137 -------TTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHT 194
                   .|.|..|..|...||..|          |.:..||  :..|..|.|  :.:..:.|..
  Rat  1745 QKADQDPDTNECIPGISTVPSLPDN----------PFSHPDK--LKRMSKSVP--AFLQDESDDR 1795

  Fly   195 KIDMT------LYRSHSQPKTINPVSLN------------------------EVRGNLHVSLGYD 229
            :.|..      |.|....|.::..:|.:                        ||:|::..::.|.
  Rat  1796 ETDTASESSYQLRRYKKSPSSLTNLSSSSGMTSLSSASGSVMSVYSGDFGNLEVKGSVQFAIDYV 1860

  Fly   230 PVGGLLNVRLLEAQNL----QPRQFSGTADPYAKVRLLPDKKNFW--QTRIHKRTLNPVFDEQFV 288
            .....|:|.:.:.::|    ..:|.|   |||.|..|||||....  :|.:.|:|||||::|...
  Rat  1861 ESLKELHVFVAQCKDLAAADAKKQRS---DPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILR 1922

  Fly   289 FEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLD----LSEQLKLWTPLSSASAQDMKV 349
            :::...|:..:.:.:.::..|.:.|:..:|..:|.|...|    .::||| |.||...:|   .|
  Rat  1923 YKIERQVLKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDSKQNKQLK-WYPLKRKTA---PV 1983

  Fly   350 DL-----GDIMVSLAYLPS-----------------AERLMVVLIKARNLRIVDDARNSSDPYVK 392
            .|     |::.::|.|:|.                 .|.|.:.|::..:|       ||   :||
  Rat  1984 ALETENRGEMKLALQYVPEPSPGKKLPTTGEVHIWVKECLDLPLLRGSHL-------NS---FVK 2038

  Fly   393 VTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFD-VAKETLKNCVLEFTVVHDGLLGSSEILGRT 456
            .|:| |...:..::||.....|.|||:|..:.:| ...|.|....:|.| |.|....:::.||..
  Rat  2039 CTIL-PDTSRKSRQKTRAVGKTSNPVFNHTMVYDGFRPEDLMEACVELT-VWDHYKLTNQFLGGL 2101

  Fly   457 LIG------NSPEV-----RTEEKIFFEEVFRAKNATAQWVPLQEPANNLATSAKSSK 503
            .||      ...||     .:||...:|::..:.|.   ||....|...|.. ||.||
  Rat  2102 RIGFGTGKSYGTEVDWMDSTSEEAALWEKMVNSPNT---WVEAMLPLRMLLI-AKISK 2155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	38/132 (29%)
		C2B_Synaptotagmin	352..488	CDD:175975	41/164 (25%)
Sytl2	NP_001101962.2	PHD_SF	5..>51	CDD:473978
		rad2	<197..>425	CDD:273166
		PTZ00108	<1592..1812	CDD:240271	42/210 (20%)
		C2A_SLP-1_2	1850..1977	CDD:176039	36/130 (28%)
		C2B_SLP_1-2-3-4	1990..2146	CDD:175987	42/170 (25%)