DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and SYT10

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_945343.1	Gene:	SYT10 / 341359	HGNCID:	19266	Length:	523	Species:	Homo sapiens

Alignment Length:	523	Identity:	155/523 - (29%)
Similarity:	248/523 - (47%)	Gaps:	103/523 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNW--------------FEQNLLESANEKDE 69
            |||::.:.|..|...|.:..|...::      ::|.|              ..|::..:..|..|
Human    51 DISVSLLAVVVSFCGLALLVVSLFVF------WKLCWPCWKSKPVTSNITTLPQSISSAPTEVFE 109

  Fly    70 DQQREALVAGAVGYNVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTST------- 127
            .::::.:          ..||.|..|       .:.| ::|.....|.  :||.|.:.
Human   110 TEEKKEI----------KENEKPAVK-------AIEP-AIKISHTSPD--IPAEVQTALKEHLIK 154

  Fly   128 -AAIQQQVSNTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKL 191
             |.:|:|:          |.||.|.:.::..             :|:     |.:.:|||::..:
Human   155 HARVQRQI----------TEPTSSTRHSSFR-------------RHL-----PRQMQVSSVDFSM 191

  Fly   192 DHT-------------KIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQ 243
            ...             :|...||:..|.....|.....::.|.|:.:|.||....||.|::::|.
Human   192 GTEPVLQRGETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKAL 256

  Fly   244 NLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDF 308
            :|..:.|:||:|||.|:.||||:|..:|||:|::||||:|||.|.|.|....:..|.:...:|||
Human   257 DLPAKDFTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDF 321

  Fly   309 DAYSRHVCIGGSKLHLANL----DLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMV 369
            |.:|||..||  ::.|.||    |||.:..:|..:..|:.:  .:|||:||.||.|||:|.|:.:
Human   322 DRFSRHDMIG--EVILDNLFEVSDLSREATVWKDIHCATTE--SIDLGEIMFSLCYLPTAGRMTL 382

  Fly   370 VLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKN 434
            .:||.|||:.: |...||||||||:|:.. |:::|||||..::.|||||||||:.||:..|.:..
Human   383 TVIKCRNLKAM-DITGSSDPYVKVSLMCE-GRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQ 445

  Fly   435 CVLEFTVVHDGLLGSSEILGRTLIGNSPEVRTEEKIFFEEVFRAKNATAQWVPLQE-PANNLATS 498
            ..|...|:....:|.:|::|....|...|....:. :.|.:...:.....|.||.| |..  |||
Human   446 VSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDH-WNEMLAYHRKPITHWHPLLELPGR--ATS 507

  Fly   499 AKS 501
            ..|
Human   508 FDS 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	53/126 (42%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	52/135 (39%)
SYT10	NP_945343.1	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	13..35
		C2A_Synaptotagmin-1-5-6-9-10	232..356	CDD:176031	53/125 (42%)
		C2B_Synaptotagmin-3-5-6-9-10	365..498	CDD:176048	52/135 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.780