DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and PLA2G4D

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_828848.3	Gene:	PLA2G4D / 283748	HGNCID:	30038	Length:	818	Species:	Homo sapiens

Alignment Length:	154	Identity:	49/154 - (31%)
Similarity:	79/154 - (51%)	Gaps:	19/154 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 LNVRLLEAQNLQPRQFSGTADPYAKVRL--LPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVID 297
            |.||:|||:||:.......||||..::|  .|..|  ::|:....|.:||::|.|.|.:.:.|
Human    24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMK--FKTKTLTDTSHPVWNEAFRFLIQSQV-- 84

  Fly   298 KRTVEILLYDFDAYSR-HVCIGGSKLHLANLDLSEQL--KLWTPLSSASAQ-DMKVDLGDIMVSL 358
            |..:|:.:||.|:.:. .:|.  ..|:    |:||.|  ||.....|.|.| :.::|:..:|...
Human    85 KNVLELSIYDEDSVTEDDICF--KVLY----DISEVLPGKLLRKTFSQSPQGEEELDVEFLMEET 143

  Fly   359 AYLPSAERLMV-VLIKARNLRIVD 381
            :..|  |.|:. .:|.||.|..:|
Human   144 SDRP--ENLITNKVIVARELSCLD 165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	36/110 (33%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	9/31 (29%)
PLA2G4D	NP_828848.3	C2_cPLA2	23..141	CDD:176001	40/126 (32%)
		cPLA2_Grp-IVB-IVD-IVE-IVF	269..811	CDD:132840
		Substrate binding. /evidence=ECO:0000269\|PubMed:27220631, ECO:0007744\|PDB:5IXC, ECO:0007744\|PDB:5IZR	330..331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900