DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and Sytl1

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_113570.2	Gene:	Sytl1 / 269589	MGIID:	1933365	Length:	568	Species:	Mus musculus

Alignment Length:	465	Identity:	106/465 - (22%)
Similarity:	192/465 - (41%)	Gaps:	92/465 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 ESANEKDEDQQREALVAGAVGYNVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTS 126
            |...|:.:||:.|....|..|..|...:.            .|.|.....:::.|   .||...:
Mouse   169 EGQEEEPQDQECELEAPGEGGVQVAEADP------------ELDPEQKAEQESQP---TPAQSKA 218

  Fly   127 TAAIQQQVSNTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAK- 190
            |:.|.:     ..|.||...|:                    .|:     |..|...|||:|:.
Mouse   219 TSKILE-----NGEEAPGLGPS--------------------LDR-----MLSSSSSVSSLNSST 253

  Fly   191 LDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTAD 255
            |..:.:.::   ..::..|:      :|||::..||.|:|....|.|::::.|.|...: ...:|
Mouse   254 LSGSLMSLS---GEAEAGTV------QVRGSVLFSLRYEPGTSELRVQVIQCQGLAAAR-RRRSD 308

  Fly   256 PYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGS 320
            ||.|..|||||::..:|.:.||.|||:|:|.....|....:..|.:.:.::..::..|::.:|..
Mouse   309 PYVKSYLLPDKQSKRKTSVKKRNLNPIFNETLRHSVQQADLPGRVLSLSVWHRESLGRNIFLGEV 373

  Fly   321 KLHLANLDLSEQLKLWTPLSS--ASAQDMKVDLGDIMVSLAYLPSAE---------RLMVVLIKA 374
            ::.|...:...: ..|.||..  ..:.|.....|.:.:||.|:|:..         .|...:.:|
Mouse   374 EVPLDTWNWDSE-ATWLPLQPRVPPSPDELPSRGLLSLSLKYVPAGSEGGGQPQSGELHFWVKEA 437

  Fly   375 RNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFD-VAKETLKNCVLE 438
            ::|  |.....|.|.|::.::| |...:..:::|.|.|.:|:||:|..:.:| .....|:....|
Mouse   438 QSL--VPLRPGSLDTYIQCSVL-PDDSRASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAE 499

  Fly   439 FTVVHDGLLGSSEILGRTL---IGNSPEVRT-------EEKIFFEEVFRAKNATAQWV----PLQ 489
            .::...|.|.|.::.|..|   .|:|..::.       |||..::.:.   ....:||    ||:
Mouse   500 LSLWDHGALASRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQTLL---ERPCEWVDGLLPLR 561

  Fly   490 EPANNLATSA 499
               .||...|
Mouse   562 ---TNLVPRA 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	36/122 (30%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	36/159 (23%)
Sytl1	NP_113570.2	PHD_SF	35..>99	CDD:389947
		NESP55	<92..230	CDD:115071	16/80 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..255		26/130 (20%)
		C2	273..392	CDD:387358	34/120 (28%)
		C2B_SLP_1-2-3-4	405..561	CDD:175987	37/161 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810