Protein Alignment Sytalpha and Syt3

DIOPT Version :9

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_061995.1
• Gene: Syt3 / 25731
• RGDID: 3805
• Length: 588
• Species: Rattus norvegicus
• Alignment Length: 565
• Identity: 163/565 - (28%)
• Similarity: 259/565 - (45%)
• Gaps: 112/565 - (19%)

  Fly    17 EEDISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNLLESANEKDEDQQREAL----- 76
            :.|||::.:.|.  |:|..:..:|.:|:.:    ::|.|...          .|:...|:
  Rat    49 DADISVSLLSVI--VTFCGIVLLGVSLFVS----WKLCWVPW----------RDKGGSAVGGGPL 97

  Fly    77 ---------VAGAVGYNVDNVNEVPRGKYSSGN-------------AGNLSPTSL-KSEDNDPAF 118
                     :||.||....::.....|....|.             |..|.|..| .||..:|::
  Rat    98 RKDLAPGVGLAGLVGGGGHHLGASLGGHPLLGGPHHHAHPAHHPPFAELLEPGGLGGSEPPEPSY 162

  Fly   119 -----WVPASVTSTAAIQQQVSNTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVV---- 174
                 :..|:|.|..|...:.|.|:.| .|....|||  ...|...|...:|.|:|.:.|.
  Rat   163 LDMDSYPEAAVASVVAAGVKPSQTSPE-LPSEGGTGS--GLLLLPPSGGGLPSAQSHQQVTSLAP 224

  Fly   175 LAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSL----------NEVRGNLHVSLGYD 229
            ...:|:.||  .:..:...|:.|.:   |..:|..: |:.|          .:::..|:...|..
  Rat   225 TTRYPALPR--PLTQQTLTTQADPS---SEERPPAL-PLPLPGGEEKAKLIGQIKPELYQGTGPG 283

  Fly   230 -------------PVGGL------------LNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNF 269
                         |.|.:            |.||:|:|.:|..:..:|.:|||.|:.||||:|..
  Rat   284 GRRTGGGSGEAGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKK 348

  Fly   270 WQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLAN-LDLSEQ- 332
            :||::|::||||:|:|.|.|.|....:.:|.:...:||||.:|||..||  ::.|.| |:|:||
  Rat   349 FQTKVHRKTLNPIFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIG--QVVLDNLLELAEQP 411

  Fly   333 --LKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTL 395
              ..||..:....::  |.|||::..||.|||:|..|.|.:|||.||:.: |....||||||.:|
  Rat   412 PDRPLWRDILEGGSE--KADLGELNFSLCYLPTAGLLTVTIIKASNLKAM-DLTGFSDPYVKASL 473

  Fly   396 LGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIGN 460
            :.. |:::|||||.:::.||||.|||||.||||.|:::|..|...||....:|.:|::|...:|
  Rat   474 ISE-GRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVG- 536

  Fly   461 SPEVRTE--EKIFFEEVFRAKNATAQWVPLQEPANNLATSAKSSK 503
             ||....  .:.:.|.:...:.....|..|.| ...|::..|..|
  Rat   537 -PEAADPHGREHWAEMLANPRKPVEHWHQLVE-EKTLSSFTKGGK 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	50/151 (33%)
		C2B_Synaptotagmin	352..488	CDD:175975	54/137 (39%)
Syt3	NP_061995.1	Cysteine motif. /evidence=ECO:0000250|UniProtKB:O35681	10..34
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	129..161		7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..222		13/41 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..257		4/22 (18%)
		C2A_Synaptotagmin-1-5-6-9-10	297..422	CDD:176031	48/126 (38%)
		C2B_Synaptotagmin-3-5-6-9-10	431..565	CDD:176048	54/137 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.780