Protein Alignment Sytalpha and SYT14

DIOPT Version :10

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_006711325.1
• Gene: SYT14 / 255928
• HGNCID: 23143
• Length: 864
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 131/545 - (24%)
• Similarity: 202/545 - (37%)
• Gaps: 110/545 - (20%)

  Fly    14 VIREEDISLAQIGVYASVSFLVVSAVG---AALYTTCSKRYRLNWFEQNLLESANEKDEDQQR-E 74
            :|.|:|.|......:.|.|.....|:|   .||..|.:.|..|....|.     |...|.:|: .
Human   361 IIPEKDNSYMDKDEHGSSSESEDEALGKYHEALSRTHNSRLPLADSRQR-----NYAWETRQKYS 420

  Fly    75 ALVAGAVGY----NVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDPAF-WVPASVTSTAAIQQQV 134
            .|.|...||    ::|..|.:.|.: .:.....|.|...:.:...|.. ..|:.:..:.......
Human   421 PLSAEYDGYSSEASIDEGNCIQRMR-RTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCEFSHC 484

  Fly   135 SNTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMH--------PSRPRVSSMNAKL 191
            ||         ||.          ||....|...|..|.:.:.|        ||
Human   485 SN---------SPR----------CSYNKCPSEGSTGHEIESFHNKGYEEDVPS----------- 519

  Fly   192 DHTKI----DMTLYRSHSQ-PKTINPVSLNEVR-GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQF 250
            |.|.:    ||:...|.|| ||..:|..  |.: |.|.|:..||.....|.|.:....::.....
Human   520 DSTAVLSPEDMSAQGSSSQLPKPFDPEP--EAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNR 582

  Fly   251 SGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVF-EVTAGVIDKRTVEILLYDFDAYSRH 314
            :|.......:.|||.||...:|.| :|...|||.|.|.| .|.:.:|....|...||......:.
Human   583 TGGNSWQVHLVLLPIKKQRAKTSI-QRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKE 646

  Fly   315 VCIGGSKLHLANLDLSEQLKLWTPL----------------------SSASAQDMK-VDLGDIMV 356
            ..:|....:|..|:|..::.|...|                      |::|.|.:: ..:.:|::
Human   647 KIVGEKIFYLTKLNLQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSESTSSCQSLEHGSVPEILI 711

  Fly   357 SLAYLPSAERLMVVLIKARNLRIVDDARNSS------------------DPYVKVTLLGPGGKKI 403
            .|.|..:..||...:||..:.:.:...|..:                  |.|||:|||...|:::
Human   712 GLLYNATTGRLSAEVIKGSHFKNLAANRPPNGLFCCLKHLIGGQVYIIRDTYVKLTLLNSMGQEM 776

  Fly   404 KKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIG--NSPEVRT 466
            .|.||.::||..||||.|...|.||...|.:..|..:|.:...:...|::|...:|  :|.|
Human   777 SKCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGE--- 838

  Fly   467 EEKIFFEEVFRAK-NATAQWVPLQE 490
            ||...:.|:..:| ....:|..|.|
Human   839 EELNHWTEMKESKGQQVCRWHALLE 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	33/146 (23%)
		C2B_Synaptotagmin	352..488	CDD:175975	42/156 (27%)
SYT14	XP_006711325.1	C2A_Synaptotagmin-14_16	550..673	CDD:176035	33/123 (27%)
		C2B_Synaptotagmin-14_16	706..862	CDD:176053	42/158 (27%)