DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and RPH3A

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001137326.1	Gene:	RPH3A / 22895	HGNCID:	17056	Length:	694	Species:	Homo sapiens

Alignment Length:	445	Identity:	121/445 - (27%)
Similarity:	189/445 - (42%)	Gaps:	65/445 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SGNAG--NLSPTSLKS----EDNDPAFWVPASVTSTAAIQQQVSNTTEESAPPTSPTGSLKSN-- 154
            ||.||  :.||..|:.    :.:.||   |.||.|.|..|.....|...|.|...|.|.....
Human   254 SGGAGDSSRSPAGLRRANSVQASRPA---PGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKP 315

  Fly   155 --TLSYCSTTSVPI--------------ARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRS 203
              ..|...||:.|.              ||.|:    ..|||.| .|..:|..............
Human   316 EVAPSDPGTTAPPREERTGGVGGYPAVGAREDR----MSHPSGP-YSQASAAAPQPAAARQPPPP 375

  Fly   204 HSQPKTINPVSLNEVR--GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLP-- 264
            ..:.:..|....:|..  |.|..||.||.....|...:::|:.|:|...:|.||||.|:.|||
Human   376 EEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGA 440

  Fly   265 DKKNFWQTRIHKRTLNPVFDEQFVFE-VTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLD 328
            .|.|..:|:..:.|.||:::|..|:. :|...:.::|:.|.:.|.|.:..:..||.::..|..|.
Human   441 SKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLK 505

  Fly   329 LSEQ------LKLWTPLSSA----SAQDMKV-------------DLGDIMVSLAYLPSAERLMVV 370
            .:::      |:...|:..|    ||:.|.:             :.|.|:|||.|......|:|.
Human   506 PNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVG 570

  Fly   371 LIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNC 435
            :|:..:|..: ||...|||:||:.|....||| .|.||.:::.||||.:||...:|:....|...
Human   571 IIRCVHLAAM-DANGYSDPFVKLWLKPDMGKK-AKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKK 633

  Fly   436 VLEFTVVHDGLLGSSEILGRTLIGNSPEVRTEEKIFFEEVFRAKNATAQ-WVPLQ 489
            .|:.:|....:..|::.:|...:|.|  .:.|....:.|..:.|:...: |..||
Human   634 SLDISVWDYDIGKSNDYIGGCQLGIS--AKGERLKHWYECLKNKDKKIERWHQLQ 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	38/133 (29%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	42/136 (31%)
RPH3A	NP_001137326.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		FYVE_RP3A	92..171	CDD:277301
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..388		34/141 (24%)
		C2A_Rabphilin_Doc2	393..516	CDD:176000	36/122 (30%)
		C2B_Rabphilin_Doc2	553..685	CDD:176030	41/135 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910