Protein Alignment Sytalpha and Syt3

DIOPT Version :9

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001107588.1
• Gene: Syt3 / 20981
• MGIID: 99665
• Length: 587
• Species: Mus musculus
• Alignment Length: 558
• Identity: 160/558 - (28%)
• Similarity: 260/558 - (46%)
• Gaps: 99/558 - (17%)

  Fly    17 EEDISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNLLESANEKDEDQQREAL----- 76
            :.|||::.:.|.  |:|..:..:|.:|:.:    ::|.|...          .|:...|:
Mouse    49 DADISVSLLSVI--VTFCGIVLLGVSLFVS----WKLCWVPW----------RDKGGSAVGGGPL 97

  Fly    77 ---------VAGAVGYNVDNV------NEVPRGKYSSGNAGN-------LSPTSL-KSEDNDPAF 118
                     :||.||....::      :.:..|.:..|:..:       |.|..| .||..:|::
Mouse    98 RKDLAPGVGLAGLVGGGGHHLGASLGGHPLLGGPHHHGHTAHHPPFAELLEPGGLGGSEPPEPSY 162

  Fly   119 -----WVPASVTSTAAIQQQVSNTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVV---- 174
                 :..|:|.|..|...:.|.|:.| .|....|||  ...|...|...:|.|:|.:.|.
Mouse   163 LDMDSYPEAAVASVVAAGVKPSQTSPE-LPSEGGTGS--GLLLLPPSGGGLPSAQSHQQVTSLAP 224

  Fly   175 LAMHPSRPR---VSSMNAKLDHT------KIDMTLYRSHSQPKTINPVSLNEVR----------- 219
            ...:|:.||   ..::..:.|.:      .:.:.|.....:.|.|..:.....:
Mouse   225 TTRYPALPRPLTQQTLTTQADPSTEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRGGG 289

  Fly   220 --------GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHK 276
                    |.:..:|.|......|.||:|:|.:|..:..:|.:|||.|:.||||:|..:||::|:
Mouse   290 SGEAGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHR 354

  Fly   277 RTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLAN-LDLSEQ---LKLWT 337
            :||||:|:|.|.|.|....:.:|.:...:||||.:|||..||  ::.|.| |:|:||   ..||.
Mouse   355 KTLNPIFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIG--QVVLDNLLELAEQPPDRPLWR 417

  Fly   338 PLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKK 402
            .:....::  |.|||::..||.|||:|.||.|.:|||.||:.: |....||||||.:|:.. |::
Mouse   418 DILEGGSE--KADLGELNFSLCYLPTAGRLTVTIIKASNLKAM-DLTGFSDPYVKASLISE-GRR 478

  Fly   403 IKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIGNSPEVRTE 467
            :|||||.:::.||||.|||||.||||.|:::|..|...||....:|.:|::|...:|  ||....
Mouse   479 LKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVG--PEAADP 541

  Fly   468 --EKIFFEEVFRAKNATAQWVPLQEPANNLATSAKSSK 503
              .:.:.|.:...:.....|..|.| ...|::..|..|
Mouse   542 HGREHWAEMLANPRKPVEHWHQLVE-EKTLSSFTKGGK 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	49/145 (34%)
		C2B_Synaptotagmin	352..488	CDD:175975	55/137 (40%)
Syt3	NP_001107588.1	Cysteine motif. /evidence=ECO:0000269|PubMed:10531343	10..34
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..258		17/77 (22%)
		C2A_Synaptotagmin-1-5-6-9-10	297..421	CDD:176031	49/125 (39%)
		C2B_Synaptotagmin-3-5-6-9-10	430..564	CDD:176048	55/137 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.780