DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and rbf-1

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001367825.1	Gene:	rbf-1 / 175943	WormBaseID:	WBGene00004316	Length:	1123	Species:	Caenorhabditis elegans

Alignment Length:	388	Identity:	98/388 - (25%)
Similarity:	166/388 - (42%)	Gaps:	75/388 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 QVSNTTEESAPPTSPTGSLK---------SNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMN 188
            |:..:.::.|||.:|...:.         |:|.|..:.|||||.      .:.:.|......::.
Worm   775 QLRTSLDDVAPPVAPISKMNGHIVSSEPTSSTTSNQNHTSVPIP------TVPVVPEEEEEKAIT 833

  Fly   189 AKLDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGT 253
            |..:          |.|:|.::         |::.::|.|......|.:.|:.|:||:....:|.
Worm   834 ASTE----------SASEPGSL---------GSITLTLTYHSADKKLKMHLIRAKNLKAMDSNGF 879

  Fly   254 ADPYAKVRLLP--DKKNFWQTRIHKRTLNPVFDEQF-VFEVTAGVIDKRTVEILLYDFDAYSRHV 315
            :|||.|..|||  .|.....::..::||||.::|:. .:.:|....:|:.:.:.:.|.|......
Worm   880 SDPYVKFHLLPGNTKATKLTSKTIEKTLNPEWNEEMSYYGITEDDKEKKILRVTVLDRDRIGSDF 944

  Fly   316 CIGGSKLHLANLDLSEQLKLWTPLSSA------SAQDMKVDLGDIMVSLAYLPSAERLMVVLIKA 374
             :|.:::.|..|:.:|..|....|.||      :.::...|.|.|.|.|.|......|.:.:.:.
Worm   945 -LGETRIALKKLNDNEMKKFNLYLESALPVPQQTKEEENEDRGKINVGLQYNIQQGSLFININRC 1008

  Fly   375 RNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAF-----DVAKETLKN 434
            ..| :..|:...||||.||:|. |...|..:.||..::.||||.:||.|.|     |:.|:||:.
Worm  1009 VEL-VGMDSTGFSDPYCKVSLT-PITSKAHRAKTSTKKRTLNPEWNEQLQFVVPFKDLPKKTLQI 1071

  Fly   435 CVLEFTVVHDGLLGS-SEILGRTLIGNSPEVRTEEKIFFEEVFRAKNATA-QWVPLQEPANNL 495
            .|.:    ||  ||. .:.:|..|:..|                ||:... ||:...|....|
Worm  1072 GVYD----HD--LGKHDDYIGGILLSTS----------------AKDERGRQWIKCIENPGTL 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	32/125 (26%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	43/142 (30%)
rbf-1	NP_001367825.1	FYVE_2	220..342	CDD:396754
		C2A_Rabphilin_Doc2	845..967	CDD:176000	31/131 (24%)
		C2B_Rabphilin_Doc2	987..1119	CDD:176030	44/150 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910