Protein Alignment Sytalpha and SYT9

DIOPT Version :10

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_011518202.1
• Gene: SYT9 / 143425
• HGNCID: 19265
• Length: 567
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 167/508 - (32%)
• Similarity: 251/508 - (49%)
• Gaps: 64/508 - (12%)

  Fly    15 IREEDISLAQIGVYASVSFLVVSAVGAALY-TTCSKRYRLNWF---EQNLLESANEKDEDQQREA 75
            :|:.|||:       |:..|||:|.|.||: .:....::|.|.   |:.|  .:..||.:|:
Human    45 LRDPDISV-------SLLTLVVTACGLALFGVSLFVSWKLCWVPWRERGL--PSGSKDNNQE--- 97

  Fly    76 LVAGAVGYNVDNVNEVPRGKYSSGNAGNLSP------TSLKSEDNDPAFWVPASVTSTAAIQQQV 134
                .:.|.....||      ...:...|.|      :|:|.....|.  :|.| |.| .||:..
Human    98 ----PLNYMDTETNE------QENSEDFLDPPTPCPDSSMKISHTSPD--IPLS-TQT-GIQENC 148

  Fly   135 SNTTEESAPPTSPTGSLKSNTLSYCSTTSVP---IARSDKHVVLAMHPSRPRVSSMNAKLDHTKI 196
            ::........|.||.|.:.|::......|.|   |.:..|         :.:::.:.      :|
Human   149 AHGVRVQRQVTEPTSSARHNSIRRQLNLSNPDFNIQQLQK---------QEQLTGIG------RI 198

  Fly   197 DMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVR 261
            ...||:..|........|.::..|.|:..|.||.....|.|::.:|.||..:.||||:|||.|:.
Human   199 KPELYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIY 263

  Fly   262 LLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKL-HLA 325
            ||||:|...||::|::||||||||.|:|.|....::.|.:...:||||.:|||..||...: |..
Human   264 LLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFL 328

  Fly   326 NL-DLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDP 389
            :| |...:..||..:...:..:  ||||::|.||.|||:|.||.:.:||||||:.: |...:|||
Human   329 DLADFPRECILWKDIEYVTNDN--VDLGELMFSLCYLPTAGRLTITIIKARNLKAM-DITGASDP 390

  Fly   390 YVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILG 454
            ||||:|: ..|:::|||||..:|.|||||||||:.|||..|.:....|...|:....:|.:||:|
Human   391 YVKVSLM-CDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIG 454

  Fly   455 RTLIGNSPEVRTEEKIFFEEVFRAKNATAQW---VPLQEPANNLATSAKSSKN 504
            ...:||..| |.....:.|.:...:...|.|   |.::||...|.|...|..|
Human   455 VCQVGNEAE-RLGRDHWSEMLSYPRKPIAHWHSLVEIKEPHFPLRTHPSSPSN 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	52/124 (42%)
		C2B_Synaptotagmin	352..488	CDD:175975	59/138 (43%)
SYT9	XP_011518202.1	C2	221..345	CDD:472691	52/123 (42%)
		C2B_Synaptotagmin-3-5-6-9-10	354..487	CDD:176048	58/135 (43%)