DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and Doc2a

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001355284.1	Gene:	Doc2a / 13446	MGIID:	109446	Length:	405	Species:	Mus musculus

Alignment Length:	298	Identity:	91/298 - (30%)
Similarity:	143/298 - (47%)	Gaps:	37/298 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPD--KKNFWQTRIHKRTLNPV 282
            |.|...|.||....:|:.|:|.|:.|:|..|:|.||||.|:.|||.  |.|..:|:..:.|||||
Mouse    96 GTLEFDLLYDQASCMLHCRILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPV 160

  Fly   283 FDEQFVFE-VTAGVIDKRTVEILLYDFDAYSRHVCIG-----------GSKLHLANLDLSEQLKL 335
            ::|:..:. :|...|..:.:.|.:.|.|..|.:..||           ..|.|. |:.|..|:.|
Mouse   161 WNEELTYSGITDDDITHKVLRISVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHF-NICLERQVPL 224

  Fly   336 WTPLSSASA-----------------QDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDA 383
            .:|.|.::|                 ..:..:.|.|::||:|......|:|.:::..:|..: |.
Mouse   225 PSPSSMSAALRGISCYLKELEQAEQGPGLLEERGRILLSLSYSSRRHGLLVGIVRCAHLAAM-DV 288

  Fly   384 RNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLG 448
            ...|||||| |.|.|...|..|.||.|::.||||.:||...:::...||....||.||....:..
Mouse   289 NGYSDPYVK-TYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGK 352

  Fly   449 SSEILGRTLIGNSPEVRTE-EKIFFEEVFRAKNATAQW 485
            |::.:|...:|  |..|.| :|.:.:.:.:...|..:|
Mouse   353 SNDFIGGVSLG--PGARGEAQKHWNDCLHQPDTALERW 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	45/134 (34%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	44/135 (33%)
Doc2a	NP_001355284.1	Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250	1..94
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..54
		C2A_Rabphilin_Doc2	95..218	CDD:176000	41/122 (34%)
		Interaction with UNC13D. /evidence=ECO:0000250	220..405		49/173 (28%)
		C2B_Rabphilin_Doc2	259..391	CDD:176030	43/134 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000