Protein Alignment Sytalpha and SYT2

DIOPT Version :10

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_016855798.1
• Gene: SYT2 / 127833
• HGNCID: 11510
• Length: 479
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 100/270 - (37%)
• Similarity: 162/270 - (60%)
• Gaps: 4/270 - (1%)

  Fly   220 GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFD 284
            |.|..||.||.....|.|.:|:|..|......||:|||.||.||||||..::|::|::||||.|:
Human   201 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFN 265

  Fly   285 EQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPLSSASAQDMKV 349
            |.|.|:|....:..:|:.:.:||||.:|:|..||..|:.:..:||.:.::.|..|.....::.:
Human   266 ETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPE- 329

  Fly   350 DLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGT 414
            .||||..||.|:|:|.:|.|.:::|:||:.: |....||||||:.|: ..||::||:||.|::.|
Human   330 KLGDICTSLRYVPTAGKLTVCILEAKNLKKM-DVGGLSDPYVKIHLM-QNGKRLKKKKTTVKKKT 392

  Fly   415 LNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIGNSPEVRTEEKIFFEEVFRAK 479
            |||.:||:.:|::..|.::...:..||:....||.:|.:|:..:| |....||.:.:.:.:...:
Human   393 LNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVG-SNATGTELRHWSDMLANPR 456

  Fly   480 NATAQWVPLQ 489
            ...|||..|:
Human   457 RPIAQWHSLK 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	49/120 (41%)
		C2B_Synaptotagmin	352..488	CDD:175975	49/135 (36%)
SYT2	XP_016855798.1	Syt2_N	61..170	CDD:409249
		C2A_Synaptotagmin-1-5-6-9-10	199..321	CDD:176031	48/119 (40%)
		C2B_Synaptotagmin-1	331..466	CDD:176047	50/137 (36%)