Protein Alignment Sytalpha and TC2N

DIOPT Version :10

• Sequence 1: NP_001188832.1
• Gene: Sytalpha / 35068
• FlyBaseID: FBgn0261089
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_689545.2
• Gene: TC2N / 123036
• HGNCID: 19859
• Length: 490
• Species: Homo sapiens
• Alignment Length: 419
• Identity: 88/419 - (21%)
• Similarity: 158/419 - (37%)
• Gaps: 105/419 - (25%)

  Fly   111 SEDNDPAFWVPASVTSTAAIQQQVSNTTEESAPPTSPTGSLKSNTLSYCS--TTSVP----IARS 169
            |..:.|::    .|.:...:.|.:|.......||.|....|..   |.|.  |..:|    :::|
Human   117 SSQHGPSY----DVYNPFYMYQHISPDLSRRFPPRSEVKRLYG---SVCDLRTNKLPGSPGLSKS 174

  Fly   170 ------------DKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLN-EVR-- 219
                        .:|..|:..||    ||.:.|           .|....::::.::|: :.|
Human   175 MFDLTNSSQRFIQRHDSLSSVPS----SSSSRK-----------NSQGSNRSLDTITLSGDERDF 224

  Fly   220 GNLHVSLGYDPVGGLLNVRLLEAQNLQ-PRQFSGTADPYAK-VRLLPDKKNFWQTRIHKRTLNPV 282
            |.|:|.|.|:.....:.:.:|:.::|. |..:..|.....| :..||...:|..:.  |...|.:
Human   225 GRLNVKLFYNSSVEQIWITVLQCRDLSWPSSYGDTPTVSIKGILTLPKPVHFKSSA--KEGSNAI 287

  Fly   283 -FDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSE---QLKLWTPLSSAS 343
             |.|.|||.:.  :.:.:||.::........|...||...:.|..|...|   .|.: ||.|..|
Human   288 EFMETFVFAIK--LQNLQTVRLVFKIQTQTPRKKTIGECSMSLRTLSTQEMDYSLDI-TPPSKIS 349

  Fly   344 AQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDP-----YVKVTLLGPGGKKI 403
            ....:::||....::     ..|:.:.:::||.|      .:||.|     :|||.:.. .|:.|
Human   350 VCHAELELGTCFQAV-----NSRIQLQILEARYL------PSSSTPLTLSFFVKVGMFS-SGELI 402

  Fly   404 KKRKTGVQRGTLNPV-YNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIGNSPEVRTE 467
            .|:||.:.:.:...| :.|.:.|                              .||.:..|:...
Human   403 YKKKTRLLKASNGRVKWGETMIF------------------------------PLIQSEKEIVFL 437

  Fly   468 EKIFFEEVFRAKNATAQ-WVPLQEPANNL 495
            .|::.....|.|:...| |:  .|.:||:
Human   438 IKLYSRSSVRRKHFVGQIWI--SEDSNNI 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	32/130 (25%)
		C2B_Synaptotagmin	352..488	CDD:175975	27/142 (19%)
TC2N	NP_689545.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..215		8/40 (20%)
		C2A_Tac2-N	240..342	CDD:176066	24/105 (23%)
		C2B_Tac2-N	353..487	CDD:176074	31/156 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	447..449		1/1 (100%)