DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and syt9

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_002938083.2	Gene:	syt9 / 100497543	XenbaseID:	XB-GENE-1006053	Length:	509	Species:	Xenopus tropicalis

Alignment Length:	501	Identity:	155/501 - (30%)
Similarity:	247/501 - (49%)	Gaps:	63/501 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LAQIGVYASVSFLVVSAVGAALY-TTCSKRYRLNW--FEQNLLESANEKDEDQQREALVAGAVGY 83
            |:...|..|:..|:|:|.|.||: .:....::|.|  :.::.|:...|.::           :.|
Frog    46 LSDSDVSVSLLSLLVTACGLALFGVSLFVSWKLCWIPWREHGLKGITEHEQ-----------LNY 99

  Fly    84 NVDNVNEVPRGKYSSGNAG--NLSP-TSLKSEDNDPAFWVPASVTSTAAIQQQVSNTTEESA--- 142
            ...:.||   ..||....|  :|.| :|:|.....|            .||.:...:|:|:.
Frog   100 TDSDTNE---RDYSDNYLGQPSLFPESSMKISHTSP------------DIQLEAKTSTKENCVHN 149

  Fly   143 -----PPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYR 202
                 ..|.||.|.:.|::    ...:.::..|.::  .....:.:::.:.      :|...||:
Frog   150 VRMHRQITEPTSSARHNSI----RRQLNLSNPDFNI--QQFQKQEQLTGIG------RIKPELYK 202

  Fly   203 SHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKK 267
            ..|........:.::..|.|:..:.||.....|.|::.:|.||..:.||||:|||.|:.||||:|
Frog   203 QKSVETDDGRRNNSKSCGKLNFIIKYDCDLEKLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRK 267

  Fly   268 NFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIG----GSKLHLANLD 328
            ...||::|::||||||||.|:|.|....:..|.:...:||||.:|||..||    .:.|.||  |
Frog   268 TKHQTKVHRKTLNPVFDEVFLFPVPYNDLPTRKLHFSVYDFDRFSRHDVIGQVIVDNFLDLA--D 330

  Fly   329 LSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKV 393
            ...:..:|..:...:..:  |||||:|.||.|||:|.||.:.:||||||:.: |...:|||||||
Frog   331 FPRESNIWRDIEHVTNDN--VDLGDLMFSLCYLPTAGRLTITIIKARNLKAM-DITGASDPYVKV 392

  Fly   394 TLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLI 458
            :::.. |:::|||||..:|.|||||||||:.|||..|.:....|...|:....:|.:|::|...:
Frog   393 SIMCE-GRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQISLLIAVMDYDRVGHNEVIGICQV 456

  Fly   459 GNSPEVRTEEKIFFEEVFRAKNATAQWVPLQEPANNLATSAKSSKN 504
            ||..|....|. :.|.:...:...|.|.||.|.:...|.:...|.|
Frog   457 GNDAESLGREH-WSEMLSYPRKPIAHWHPLTEWSAQAAATGNGSCN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	51/126 (40%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	57/135 (42%)
syt9	XP_002938083.2	C2	219..342	CDD:387358	51/124 (41%)
syt9	XP_002938083.2	C2B_Synaptotagmin-3-5-6-9-10	352..485	CDD:176048	57/135 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920