DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and sytl4

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_031746962.1	Gene:	sytl4 / 100495134	XenbaseID:	XB-GENE-958567	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	552	Identity:	134/552 - (24%)
Similarity:	214/552 - (38%)	Gaps:	153/552 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 CSKRYRL-----NWF-EQNLLESANEKDEDQQREAL-----------VAGAVGYNVDNVNE---- 90
            |||...|     :|| :|.:...||....|..|.:|           .|.|:......:||
Frog   110 CSKEADLKKSTGDWFYDQRVNRFANRLGRDMVRMSLRQKPSANKRETTAQALLEFSQQLNEPKTR 174

  Fly    91 ----VPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTSTAAIQQQVSNTTEESAPPTSPTGSL 151
                .|:.::.|..    || .|:.:.:|.......|::|       ....:::|:|.||...||
Frog   175 KAQRSPQQQHKSSG----SP-DLRDQKSDTESTEQMSLSS-------YKTDSKKSSPSTSRRNSL 227

  Fly   152 -KSNTL-----------SYCSTTSVPIARSDKH-------------------------------- 172
             ||.||           :..:|.:||:...|:|
Frog   228 EKSATLQDAKRAQGPVGANVATLTVPVRSRDRHQSDSEGEALLGSRSAGSADESDTLFKKNPRRL 292

  Fly   173 --------VVLAMHPSRPRVSSMNAKLDHTK------IDM--------------------TLYRS 203
                    .||.:.| .|.....||..|.:|      |:|                    :..||
Frog   293 LKPADYSKSVLDLRP-EPAAPEENALGDRSKSVPRLNIEMEEEDEDIDNLVEIHRLSAGRSSLRS 356

  Fly   204 HSQPKTI-NPVSLNE---------VRGNLHVSLGYDPVGGLLNVRLLEAQNL-QPRQFSGTADPY 257
            .:...|: :.:|:..         :.|.:..|:.||....|||:.:.|.:|| ...:....::||
Frog   357 GASSSTLGSMISIYSEAGDFGNVIITGEIIFSINYDAKVQLLNILVKECRNLAYGDELKMRSNPY 421

  Fly   258 AKVRLLPDK--KNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGS 320
            .|..|||||  :...:|.|.:.|.||:::|...:.|...::..|::|:.::.:|.:.|:..:|..
Frog   422 IKSYLLPDKSRQGKRKTTIKRNTTNPMYNEVLKYIVPESMLHLRSLELSVWHYDRFGRNTFLGQV 486

  Fly   321 KLHLANLDLSEQLKLWTPLSSASAQDMKVDL----GDIMVSLAYLP-----SAER---------- 366
            .:.|.:.:....::...||......|.....    |:::|||.|:|     .:||
Frog   487 DIPLDSWNFDSLIEECLPLHGKGNMDSGAGFYNSKGELVVSLKYVPPTKPSGSERRKKKADEGGE 551

  Fly   367 LMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFD-VAKE 430
            |.|.:.:|:||..|... ..||.:||..|. |...|..||||.|.:.||||.||....:: :..|
Frog   552 LHVWIKEAKNLTAVKTG-GISDSFVKGYLF-PHKNKNTKRKTPVVKKTLNPHYNHTFVYNGIKPE 614

  Fly   431 TLKNCVLEFTVVHDGLLGSSEILG--RTLIGN 460
            .|:|..||.||.....|.|::.||  |..|||
Frog   615 DLQNVCLELTVWDREPLSSNDFLGGVRLGIGN 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	33/125 (26%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	47/127 (37%)
sytl4	XP_031746962.1	PHD_SF	15..126	CDD:419867	6/15 (40%)
		FYVE_Slp4	63..112	CDD:277303	1/1 (100%)
		C2A_SLP-4_5	382..506	CDD:175995	32/123 (26%)
		C2B_SLP_1-2-3-4	521..685	CDD:175987	47/128 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910