DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sytalpha and syt6

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_002935822.2	Gene:	syt6 / 100488667	XenbaseID:	XB-GENE-953252	Length:	528	Species:	Xenopus tropicalis

Alignment Length:	502	Identity:	151/502 - (30%)
Similarity:	240/502 - (47%)	Gaps:	79/502 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IREEDISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNLLESANEKDEDQQREALVAG 79
            |.:.|:|::.:.|...|..|.:.||...|:.   |.:.:.|..:.:..:..||..       .:.
Frog    50 ITDPDLSVSLLAVIVIVCGLALVAVFLFLFW---KLWWVPWRNKAVPSNPAEKQN-------ASS 104

  Fly    80 AVGYNVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTSTAAIQQQVSNTTEESAPP 144
            ..|.|.|......:.|.:| |.|.|. .::|.....|.  :||.|  ..::::.:...|......
Frog   105 VTGINCDKEAMADKLKDAS-NLGFLE-AAVKISHTSPD--IPAEV--QMSMKEHLMRRTRIQRQT 163

  Fly   145 TSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKT 209
            |.|..|.:..:..             :|:...||     |.|::...|..::            |
Frog   164 TEPASSTRHTSFK-------------RHLNRQMH-----VCSVDFGTDTLQV------------T 198

  Fly   210 INPVSLNEVR----------------------GNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSG 252
            ..|.|:..::                      |.::.:|.||.....|.||:|:|.:|..:.|.|
Frog   199 EQPTSIGRIKPELYKQKSVDSEDIKKDDAKTCGKINFTLKYDYEIETLIVRILKAFDLPAKDFCG 263

  Fly   253 TADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCI 317
            ::|||.|:.||||:|..:|||:|::||||.|||.|.|.|....:..|.:.:.::|||.:|||..|
Frog   264 SSDPYVKIYLLPDRKRKFQTRVHRKTLNPTFDESFHFPVPYDDLPNRKLHLSVFDFDRFSRHDMI 328

  Fly   318 GGSKLHLANL----DLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLR 378
            |  ::.|.||    |||.:..:|..:..|:.:  .||||:||.||.|||:|.||.:.:||.|||:
Frog   329 G--EVILENLFEESDLSRESSIWKDIQYATTE--SVDLGEIMFSLCYLPTAGRLTLTVIKCRNLK 389

  Fly   379 IVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVH 443
            .: |....|||||||:|| ..|:::||:||.:::.||||.||||:.||:..|.:....|..:|:.
Frog   390 AM-DITGYSDPYVKVSLL-CDGRRLKKKKTTIKKNTLNPTYNEAIIFDIPPENMDQVSLLISVMD 452

  Fly   444 DGLLGSSEILGRTLIGNSPEVRTEEKIFFEEVFRAKNATAQWVPLQE 490
            ...:|.:||:|...:|||.|....:. :.|.:...:.....|.||.|
Frog   453 YDRVGHNEIIGVCRVGNSTEGLGRDH-WNEMLAYPRKPITHWHPLVE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	51/148 (34%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	54/135 (40%)
syt6	XP_002935822.2	COG5038	<90..>331	CDD:227371	72/285 (25%)
		C2A_Synaptotagmin-1-5-6-9-10	229..354	CDD:176031	51/126 (40%)
		C2B_Synaptotagmin-3-5-6-9-10	363..496	CDD:176048	54/135 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920