DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and rph3a

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_031748610.1	Gene:	rph3a / 100487950	XenbaseID:	XB-GENE-5881709	Length:	703	Species:	Xenopus tropicalis

Alignment Length:	486	Identity:	122/486 - (25%)
Similarity:	210/486 - (43%)	Gaps:	70/486 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EQNLLESANEKDEDQQREALVAGAVGYNVDN-VNEVPRGKYSSGNAGNLSPTSLKSEDN-DPAFW 119
            |..:..|.:|.:.::.|::...|     ||| :|..|.|.....:.....|||.....| .|...
Frog   242 ESRMAPSGSEYEGEETRDSSYGG-----VDNDINRSPGGVKRGSSVQGTRPTSAVQGSNIQPTQQ 301

  Fly   120 VPASVTSTAAIQQQVSNTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDK------HVVLAMH 178
            .|.:....||.....:...||....|.|....:       ||.|..:.|::|      ..|....
Frog   302 APPASARPAARPTPANRFPEEQGGTTLPASQPE-------STYSASVPRNEKADSFTPQGVRQDR 359

  Fly   179 PSR---------PRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLNEVR--GNLHVSLGYDPVG 232
            |.|         |.|::.:|:...|:        ..:.:..|....:|..  |:|..||.||...
Frog   360 PLRQAASYTSSVPTVAAPSARQPQTQ--------DEEEEEANSYDSDEATTLGSLEFSLFYDQEN 416

  Fly   233 GLLNVRLLEAQNLQPRQFSGTADPYAKVRLLP--DKKNFWQTRIHKRTLNPVFDEQFVFE-VTAG 294
            ..|:..:::|:.|:|...:|.||||.|:.|||  .|.|..:|:..:.|.||:::|..|:. :|..
Frog   417 NSLHCGIIKAKGLKPMDSNGLADPYVKLHLLPGASKANKLRTKTLRNTRNPIWNETLVYHGITDE 481

  Fly   295 VIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSEQ------LKLWTPLSSA----SAQDMKV 349
            .:.::|:.|.:.|.|.:..:..||.::..|..|..:::      |:...|:..|    |.:.|.:
Frog   482 ELQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQKKSFNVCLERVIPMKRAGTTGSVRGMAL 546

  Fly   350 ------------DLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKK 402
                        :.|.|:|||.|......|:|.:::..:|..: ||...|||:||:.|....|||
Frog   547 YEDENDRGGDVEERGKILVSLMYNTQQGGLIVGIVRCVHLAAM-DANGYSDPFVKLWLKPDMGKK 610

  Fly   403 IKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIG-NSPEVRT 466
             .|.||.:::.||||.:||...:::....|....|:.:|....:..|::.:|...:| |:...|.
Frog   611 -AKNKTQIKKKTLNPEFNEEFFYEIKHSDLAKKQLDVSVWDYDIGKSNDYIGGCQLGINAKGERL 674

  Fly   467 EEKIFFEEVFRAKNATAQWVPLQEPANNLAT 497
              |.::|.:........:|..||. .|::|:
Frog   675 --KHWYECLKNKDKKIERWHVLQN-ENHVAS 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	38/133 (29%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	40/136 (29%)
rph3a	XP_031748610.1	FYVE_RP3A	92..171	CDD:277301
		C2A_Rabphilin_Doc2	403..526	CDD:176000	36/122 (30%)
		C2B_Rabphilin_Doc2	562..694	CDD:176030	39/135 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910