DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sytalpha and syt7b

DIOPT Version :9

Sequence 1:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001232886.1	Gene:	syt7b / 100334336	ZFINID:	ZDB-GENE-090601-6	Length:	488	Species:	Danio rerio

Alignment Length:	514	Identity:	145/514 - (28%)
Similarity:	237/514 - (46%)	Gaps:	88/514 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNL-------LESANEKDEDQQREALV 77
            :.|..:|:...|.:||      ||...|      .|.::.|       :|:|...|     ...|
Zfish    18 VFLVSVGLTVCVVWLV------ALCGVC------GWCQRKLGMRNKPGVETAGTPD-----SVSV 65

  Fly    78 AG-AVGYN-VDNVNEVPRGKYSSGNAG----------------NLSPTSLKSEDNDPAF------ 118
            :| ..|.| ..|.|::.|..:::.::.                |:||   .:...||..
Zfish    66 SGRGRGENKAINHNDLDRDFWNNNDSCSVQQRWSSYPPKEFLLNMSP---YAPYGDPRLTPKEGK 127

  Fly   119 WVPASVTSTAAIQQQVSNTTE-ESAP---PTSPTG--SLKSNTLSYCSTTSVPIARSDKHVVLAM 177
            .|..|:....|.|...:|..: :.||   .|.||.  |.|..:.....|......|:|.:
Zfish   128 MVVLSLAIGLAEQDDFANLPDLQEAPADTETPPTDKRSNKPGSSPKGQTPDESHRRTDAN----- 187

  Fly   178 HPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKT-INPVSLNEVRGNLHVSLGYDPVGGLLNVRLLE 241
                   ||::...:....||.:....|:.:. ..||.  |..|.:..|:||......|.|::|:
Zfish   188 -------SSVSDLANSVTSDMLMLSPGSEEEEHEGPVC--EKLGRIQFSVGYSFQDSTLTVKILK 243

  Fly   242 AQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGV----IDKRTVE 302
            .|:|..:.||||:||:.|:.||||||:..:|::.::.|||.::|.|:||   |.    :.:||:.
Zfish   244 GQDLPAKDFSGTSDPFVKLYLLPDKKHKLETKVKRKNLNPHWNETFLFE---GFPYEKVVQRTLY 305

  Fly   303 ILLYDFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERL 367
            :.:.|:|.:||:..||...:.|..::|.....||..|...|  |.....||::|||.|.|:|..:
Zfish   306 LQVLDYDRFSRNDPIGEVSIPLNKVELVPMQTLWKELKPCS--DGSGSRGDLLVSLCYNPTANII 368

  Fly   368 MVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETL 432
            .|.:||||||:.: |...:|||||||.|:.. .|:::|:||.|.:..||||:||:..|||....|
Zfish   369 TVSIIKARNLKAM-DIGGTSDPYVKVWLMNK-DKRVEKKKTVVMKRCLNPVFNESFPFDVPAHVL 431

  Fly   433 KNCVLEFTVVHDGLLGSSEILGRTLIG--NSPEVRTEEKIFFEEVFRAKNATAQWVPLQ 489
            :...:..||:....|..::::|:..:.  :.|   .|.|.:.:.:...:.|.|||..|:
Zfish   432 RETTIVITVMDKDRLSRNDVIGKIYLSWKSGP---AEVKHWKDMMSHPRTAVAQWHALK 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	44/126 (35%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	50/137 (36%)
syt7b	NP_001232886.1	C2A_Synaptotagmin-7	220..344	CDD:176032	44/126 (35%)
syt7b	NP_001232886.1	C2B_Synaptotagmin-7	352..487	CDD:176050	50/139 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920