DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oli and Atoh8

DIOPT Version :9

Sequence 1:	NP_001188830.1	Gene:	Oli / 35066	FlyBaseID:	FBgn0032651	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_722473.1	Gene:	Atoh8 / 71093	MGIID:	1918343	Length:	322	Species:	Mus musculus

Alignment Length:	219	Identity:	59/219 - (26%)
Similarity:	84/219 - (38%)	Gaps:	66/219 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PGLPNHGHMPIPPTANMLGGQHP-----------------APTASPPQSVPGRRTPLGSVGLGGF 58
            ||||.   .|.||.:..|....|                 ||.|.|.||.|
Mouse   121 PGLPT---PPPPPASQSLAPGDPEAHSFREQALRPRILLCAPPARPTQSAP-------------- 168

  Fly    59 YAQGMGMSQQPPT--DENKPGPSAPEKPLSPTAAAIAAIAISGGTTTVAVSSGGASGSGSNSGKQ 121
                    ..||.  .|:...|:.|.:|...:.::|:.:..:....:.| |.....|..:.:..:
Mouse   169 --------LAPPAAPQESPVRPAPPTRPGESSYSSISHVIYNNHPDSSA-SPRKRPGEATAASTE 224

  Fly   122 KNRQGKTVRLNINARERRRMHDLNDALDELRSVIP-YAHSPSVRKLSKIATLLLAKNYILMQQNA 185
            .....:|.||..|||||.|:|.::.|.:.||..:| |::.   :||||:|.|.:|.||||
Mouse   225 IKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYG---QKLSKLAILRIACNYIL----- 281

  Fly   186 LEELRRLLAYIQSTTGAAPLDLGA 209
              .|.||          |.||..|
Mouse   282 --SLARL----------ADLDYSA 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oli	NP_001188830.1	HLH	134..188	CDD:197674	23/54 (43%)
Atoh8	NP_722473.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..144		9/25 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..221		16/84 (19%)
		Basic motif, degenerate. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	231..244		8/12 (67%)
		HLH	232..283	CDD:278439	25/60 (42%)
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	245..283		17/47 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810