DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oli and NEUROD4

DIOPT Version :9

Sequence 1:	NP_001188830.1	Gene:	Oli / 35066	FlyBaseID:	FBgn0032651	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_067014.2	Gene:	NEUROD4 / 58158	HGNCID:	13802	Length:	331	Species:	Homo sapiens

Alignment Length:	159	Identity:	48/159 - (30%)
Similarity:	67/159 - (42%)	Gaps:	47/159 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 QGMGMSQQPPTDENKPGPSAPEKPLSPTAAAIAAIAISGGTTTVAVSSGGASGSGSNSGKQKNRQ 125
            :|:|...:...:|::||          |...::::       |....|..........|::..|:
Human    23 KGLGSQNEVKEEESRPG----------TYGMLSSL-------TEEHDSIEEEEEEEEDGEKPKRR 70

  Fly   126 G--------------KTVRLNINARERRRMHDLNDALDELRSVIP-YAHSPSVRKLSKIATLLLA 175
            |              :..|:..|||||.|||.||||||.||.|:| |:   ..:|||||.||.||
Human    71 GPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYS---KTQKLSKIETLRLA 132

  Fly   176 KNYILMQQNALEELRRLLAYIQSTTGAAP 204
            :|||......||            ||..|
Human   133 RNYIWALSEVLE------------TGQTP 149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oli	NP_001188830.1	HLH	134..188	CDD:197674	32/54 (59%)
NEUROD4	NP_067014.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..80		11/73 (15%)
		HLH	88..144	CDD:238036	32/58 (55%)
		Neuro_bHLH	146..264	CDD:289310	2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..265
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810