DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oli and NEUROD1

DIOPT Version :9

Sequence 1:	NP_001188830.1	Gene:	Oli / 35066	FlyBaseID:	FBgn0032651	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_002491.3	Gene:	NEUROD1 / 4760	HGNCID:	7762	Length:	356	Species:	Homo sapiens

Alignment Length:	165	Identity:	53/165 - (32%)
Similarity:	72/165 - (43%)	Gaps:	55/165 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QQPPTDENKPGPSAPEKPLSPTAAAIAAIAISGGTTTVAVSSGGASGSGSNSGKQKNRQGKTVRL 131
            ::...|:.||....|:|                                ....|.:..:.|..|:
Human    72 EEEEDDDQKPKRRGPKK--------------------------------KKMTKARLERFKLRRM 104

  Fly   132 NINARERRRMHDLNDALDELRSVIP-YAHSPSVRKLSKIATLLLAKNYILMQQNALEELRRLLAY 195
            ..|||||.|||.||.|||.||.|:| |:   ..:|||||.||.||||||.    ||.|:.|
Human   105 KANARERNRMHGLNAALDNLRKVVPCYS---KTQKLSKIETLRLAKNYIW----ALSEILR---- 158

  Fly   196 IQSTTGAAPLDLGAFPAAAKLQALLQGPHNEPPTS 230
                :|.:| ||.:|     :|.|.:| .::|.|:
Human   159 ----SGKSP-DLVSF-----VQTLCKG-LSQPTTN 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oli	NP_001188830.1	HLH	134..188	CDD:197674	33/54 (61%)
NEUROD1	NP_002491.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		5/53 (9%)
		bHLH_TS_NeuroD1	75..160	CDD:381562	43/131 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	87..93		1/37 (3%)
		Neuro_bHLH	160..284	CDD:403655	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810