DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oli and Twist1

DIOPT Version :9

Sequence 1:	NP_001188830.1	Gene:	Oli / 35066	FlyBaseID:	FBgn0032651	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_035788.1	Gene:	Twist1 / 22160	MGIID:	98872	Length:	206	Species:	Mus musculus

Alignment Length:	194	Identity:	57/194 - (29%)
Similarity:	79/194 - (40%)	Gaps:	37/194 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PIPPTANMLGGQHPAPTASPPQS--------VPGRRTPLGSVGLGGFYAQGMGMSQQPPTD-ENK 75
            |:.|..:.|......|....|.|        ...||:..||.|.||....|:|...:|.:. :.|
Mouse     9 PVSPADDSLSNSEEEPDRQQPASGKRGARKRRSSRRSAGGSAGPGGATGGGIGGGDEPGSPAQGK 73

  Fly    76 PGPSAPEKPLSPTAAAIAAIAISGGTTTVAVSSGGASGSGSNSG---KQKNRQGKTVRLNINARE 137
            .|..:                 :||........||..|.||:||   .|...:.:|.|:..|.||
Mouse    74 RGKKS-----------------AGGGGGGGAGGGGGGGGGSSSGGGSPQSYEELQTQRVMANVRE 121

  Fly   138 RRRMHDLNDALDELRSVIPYAHSPSVRKLSKIATLLLAKNYI-----LMQQNALEELRRLLAYI 196
            |:|...||:|...||.:||...|.   |||||.||.||..||     ::|.:.|:......:|:
Mouse   122 RQRTQSLNEAFAALRKIIPTLPSD---KLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYV 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oli	NP_001188830.1	HLH	134..188	CDD:197674	26/58 (45%)
Twist1	NP_035788.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..109		28/116 (24%)
		HLH	113..163	CDD:306515	25/52 (48%)
		Sufficient for transactivation activity	165..195		3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910