DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Oli and Atoh1

DIOPT Version :9

Sequence 1:NP_001188830.1 Gene:Oli / 35066 FlyBaseID:FBgn0032651 Length:232 Species:Drosophila melanogaster
Sequence 2:NP_031526.1 Gene:Atoh1 / 11921 MGIID:104654 Length:351 Species:Mus musculus


Alignment Length:242 Identity:70/242 - (28%)
Similarity:89/242 - (36%) Gaps:76/242 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 QHPAP------TASPPQSVPGRRTPLGSVGLG----------------G----------FYAQGM 63
            :||.|      |..||.::..|..|:....|.                |          .::..:
Mouse    21 RHPQPHHVPPLTPQPPATLQARDLPVYPAELSLLDSTDPRAWLTPTLQGLCTARAAQYLLHSPEL 85

  Fly    64 GMSQ-QPPTDE--------NKPGPSAPEKPLSPTAAAIAAIAISGGTTTVAVSSGGASGSGSNSG 119
            |.|: ..|.||        .:.|.....|...|.........:.||   |.|...|.|...:.|.
Mouse    86 GASEAAAPRDEADSQGELVRRSGCGGLSKSPGPVKVREQLCKLKGG---VVVDELGCSRQRAPSS 147

  Fly   120 KQKNRQGKTVRLNINARERRRMHDLNDALDELRSVIPYAHSPSVRKLSKIATLLLAKNYILMQQN 184
            ||.|...|..||..|||||||||.||.|.|:||:|||..::.  :||||..||.:|:.||    |
Mouse   148 KQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNND--KKLSKYETLQMAQIYI----N 206

  Fly   185 ALEELRRLLAYIQSTTGAAPLDLGAFPAAAKLQALLQGPHNEPPTSS 231
            ||.||                          ||....|....|||:|
Mouse   207 ALSEL--------------------------LQTPNVGEQPPPPTAS 227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OliNP_001188830.1 HLH 134..188 CDD:197674 30/53 (57%)
Atoh1NP_031526.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 16..39 6/17 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 89..116 5/26 (19%)
HLH 155..213 CDD:238036 35/89 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 244..278
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 308..351
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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