DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7094 and VRK3

DIOPT Version :9

Sequence 1:	NP_609851.2	Gene:	CG7094 / 35065	FlyBaseID:	FBgn0032650	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_057524.3	Gene:	VRK3 / 51231	HGNCID:	18996	Length:	474	Species:	Homo sapiens

Alignment Length:	283	Identity:	70/283 - (24%)
Similarity:	124/283 - (43%)	Gaps:	53/283 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KNDAKYPQLIYEAKVYEQLAR------------CP--GFPTLLHYGCEKN-YNAMVMDLLGPSLE 108
            |.|||..:|..|...:::.|:            .|  ..||.:.:|..:: |..:|:..||.||:
Human   203 KLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQ 267

  Fly   109 ELFNLC-KRRFSLKTVLMLTDQLLMRIECVHERGFIHRDIKPDNFLMGLDRHCNKLYLIDFGLSK 172
            ...::. |...|.::||.:..:||..:|.:||..::|.::..:|..:..:.. :::.|..:|.:.
Human   268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQ-SQVTLAGYGFAF 331

  Fly   173 RYKDIESEIHIPY----RTDRNLTGTVRYASINAQIGVEQSRRDDMESMSYCLMYFNLGKLPWQG 233
            ||  ..|..|:.|    |:...  |.:.:.|::...|...|||.|::|:.||::.:..|.|||..
Human   332 RY--CPSGKHVAYVEGSRSPHE--GDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTN 392

  Fly   234 I---TAANKKQKYEKILEK------------KTSVTIAQLCKGFPSEFCLLMTYVRNLGFKEPPD 283
            .   |....||| :|.::|            :.|.|:.:..|           .|..|.::|.|.
Human   393 CLPNTEDIMKQK-QKFVDKPGPFVGPCGHWIRPSETLQKYLK-----------VVMALTYEEKPP 445

  Fly   284 HTYLRQIFRILFRSLN-HHYDYI 305
            :..||.....|.:.|. ..||.|
Human   446 YAMLRNNLEALLQDLRVSPYDPI 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7094	NP_609851.2	STKc_CK1	26..291	CDD:270918	65/266 (24%)
CG7094	NP_609851.2	SPS1	26..>266	CDD:223589	59/241 (24%)
VRK3	NP_057524.3	zinc_ribbon_2	4..26	CDD:289981
		DZR	5..>31	CDD:289539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..152
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:14645249	49..64
		DUF4551	<82..>150	CDD:291746
		PKc_like	155..457	CDD:304357	65/270 (24%)
		SPS1	211..>467	CDD:223589	64/272 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810